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Open Access

Prospective observational study of point-of-care creatinine in trauma

Anthony J Carden, Edgardo S Salcedo, Nam K Tran, Eric Gross, Jennifer Mattice, Jan Shepard, Joseph M Galante
DOI: 10.1136/tsaco-2016-000014 Published 12 July 2016
Anthony J Carden
1Department of Surgery, Division of Trauma and Acute Care Surgery, UC Davis Medical Center, Sacramento, California, USA
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Edgardo S Salcedo
1Department of Surgery, Division of Trauma and Acute Care Surgery, UC Davis Medical Center, Sacramento, California, USA
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Nam K Tran
2Department of Pathology and Laboratory Medicine, UC Davis Medical Center, Sacramento, California, USA
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Eric Gross
3Department of Emergency Medicine, UC Davis Medical Center, Sacramento, California, USA
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Jennifer Mattice
3Department of Emergency Medicine, UC Davis Medical Center, Sacramento, California, USA
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Jan Shepard
3Department of Emergency Medicine, UC Davis Medical Center, Sacramento, California, USA
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Joseph M Galante
1Department of Surgery, Division of Trauma and Acute Care Surgery, UC Davis Medical Center, Sacramento, California, USA
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Abstract

Background Patients with trauma are at risk for renal dysfunction from hypovolemia or urological injury. In austere environments, creatinine values are not available to guide resuscitation. A new portable device, the Stat Sensor Point-of-care (POC) Whole Blood Creatinine Analyzer, provides accurate results in <30 s and requires minimal training. This device has not been evaluated in trauma despite the theoretical benefit it provides. The purpose of this study is to determine the clinical impact of the POC device in trauma.

Methods 40 patients with trauma were enrolled in a prospective observational study. One drop of blood was used for creatinine determination on the Statsensor POC device. POC creatinine results were compared to the laboratory. Turnaround time (TAT) for POC and laboratory methods was calculated as well as time elapsed to CT scan if applicable.

Results Patients (n=40) were enrolled between December 2014 and March 2015. POC creatinine values were similar to laboratory methods with a mean bias of 0.075±0.27 (p=0.08). Mean analytical TATs for the POC measurements were significantly faster than the laboratory method (11.6±10.0 min vs 78.1±27.9 min, n=40, p<0.0001). Mean elapsed time before arrival at the CT scanner was 52.9±34.2 min.

Conclusions The POC device reported similar creatinine values to the laboratory and provided significantly faster results. POC creatinine testing is a promising development for trauma practice in austere environments and workup of a subset of stable patients with trauma. Further study is warranted to determine clinical impact, both in hospital-based trauma and austere environments.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Prospective observational study of point-of-care creatinine in trauma
Anthony J Carden, Edgardo S Salcedo, Nam K Tran, Eric Gross, Jennifer Mattice, Jan Shepard, Joseph M Galante
Trauma Surg Acute Care Open Jul 2016, 1 (1) e000014; DOI: 10.1136/tsaco-2016-000014

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Prospective observational study of point-of-care creatinine in trauma
Anthony J Carden, Edgardo S Salcedo, Nam K Tran, Eric Gross, Jennifer Mattice, Jan Shepard, Joseph M Galante
Trauma Surg Acute Care Open Jul 2016, 1 (1) e000014; DOI: 10.1136/tsaco-2016-000014
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Prospective observational study of point-of-care creatinine in trauma
Anthony J Carden, Edgardo S Salcedo, Nam K Tran, Eric Gross, Jennifer Mattice, Jan Shepard, Joseph M Galante
Trauma Surgery & Acute Care Open Jul 2016, 1 (1) e000014; DOI: 10.1136/tsaco-2016-000014
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