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Open Access

Antifibrinolytics in a rural trauma state: assessing the opportunities

James M Bardes, Amanda Palmer, Jorge Con, Alison Wilson, Gregory Schaefer
DOI: 10.1136/tsaco-2017-000107 Published 5 October 2017
James M Bardes
Division of Trauma, Acute Care Surgery and Critical Care, Department of Surgery, West Virginia University, Morgantown, West Virginia, USA
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Amanda Palmer
Division of Trauma, Acute Care Surgery and Critical Care, Department of Surgery, West Virginia University, Morgantown, West Virginia, USA
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Jorge Con
Division of Trauma, Acute Care Surgery and Critical Care, Department of Surgery, West Virginia University, Morgantown, West Virginia, USA
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Alison Wilson
Division of Trauma, Acute Care Surgery and Critical Care, Department of Surgery, West Virginia University, Morgantown, West Virginia, USA
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Gregory Schaefer
Division of Trauma, Acute Care Surgery and Critical Care, Department of Surgery, West Virginia University, Morgantown, West Virginia, USA
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    Figure 1

    Patient population. TXA, tranexamic acid.

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  • Table 1

    Demographics baseline

    TXA indicated (n=217)TXA not indicated (n=183)p Value
    Age45.542.10.57
    Male (%)73.3%82.5%0.27
    Blunt mechanism (%)70.0%89.1%0.0001
    Penetrating mechanism (n)30.0%10.9%0.0001
    % Patients receiving blood product65.9%7.1%0.0001
    Mean PRBC units (if received blood product)6.9 U3.1 U0.13
    Mean ISS2114>0.0001
    ISS ≥15 (%)65.90%44.30%>0.0001
    Mean arrival SBP (mm Hg)109.8140.6>0.001
    Arrival lactate*3.22.4>0.001
    • *Arrival lactate available for 337 patients.

    • ISS, injury severity score; PRBC, packed red blood cell; TXA, tranexamic acid.

  • Table 2

    Comparison of scene vs transfer patients

    Scene (n=265)Transfer (n=135)p Value
    TXA indicated144731
    TXA eligible137140.001
    TXA not eligible (>3 hour since injury)7590.001
    TXA received2840.497
    • TXA, tranexamic acid.

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Antifibrinolytics in a rural trauma state: assessing the opportunities
James M Bardes, Amanda Palmer, Jorge Con, Alison Wilson, Gregory Schaefer
Trauma Surg Acute Care Open Sep 2017, 2 (1) e000107; DOI: 10.1136/tsaco-2017-000107

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Antifibrinolytics in a rural trauma state: assessing the opportunities
James M Bardes, Amanda Palmer, Jorge Con, Alison Wilson, Gregory Schaefer
Trauma Surg Acute Care Open Sep 2017, 2 (1) e000107; DOI: 10.1136/tsaco-2017-000107
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Antifibrinolytics in a rural trauma state: assessing the opportunities
James M Bardes, Amanda Palmer, Jorge Con, Alison Wilson, Gregory Schaefer
Trauma Surgery & Acute Care Open Sep 2017, 2 (1) e000107; DOI: 10.1136/tsaco-2017-000107
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