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Open Access

Minor change in initial PEEP setting decreases rates of ventilator-associated events in mechanically ventilated trauma patients

Ethan Ferrel, Kristina M Chapple, Liviu Gabriel Calugaru, Jennifer Maxwell, Jessica A Johnson, Andrew W Mezher, James N Bogert, Hahn Soe-Lin, Jordan A Weinberg
DOI: 10.1136/tsaco-2020-000455 Published 10 May 2020
Ethan Ferrel
1Creighton University School of Medicine Phoenix Regional Campus, Phoenix, Arizona, USA
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Kristina M Chapple
1Creighton University School of Medicine Phoenix Regional Campus, Phoenix, Arizona, USA
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  • ORCID record for Kristina M Chapple
Liviu Gabriel Calugaru
2Department of Surgery, Dignity Health/St. Joseph’s Hospital and Medical Center, Phoenix, Arizona, USA
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Jennifer Maxwell
2Department of Surgery, Dignity Health/St. Joseph’s Hospital and Medical Center, Phoenix, Arizona, USA
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Jessica A Johnson
2Department of Surgery, Dignity Health/St. Joseph’s Hospital and Medical Center, Phoenix, Arizona, USA
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Andrew W Mezher
1Creighton University School of Medicine Phoenix Regional Campus, Phoenix, Arizona, USA
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James N Bogert
1Creighton University School of Medicine Phoenix Regional Campus, Phoenix, Arizona, USA
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Hahn Soe-Lin
1Creighton University School of Medicine Phoenix Regional Campus, Phoenix, Arizona, USA
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Jordan A Weinberg
2Department of Surgery, Dignity Health/St. Joseph’s Hospital and Medical Center, Phoenix, Arizona, USA
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  • Figure 1
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    Figure 1

    Ventilator-associated events surveillance algorithm (adapted from Centers for Disease Control and Prevention (CDC) 20192). Materials are developed by CDC and free to use via the CDC website. Reference to specific commercial products, manufacturers, companies, or trademarks does not constitute its endorsement or recommendation by the US government, Department of Health and Human Services, or CDC. FiO2, fractional inspired oxygen; PEEP, positive end-expiratory pressure.

  • Figure 2
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    Figure 2

    Initial ventilator parameters guideline, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona. ABG, arterial blood gas; A/C, asssit control; FiO2, fractional inspired oxygen; I:E, inpiration to expiration ratio; MV, minute ventilation; PEEP, positive end-expiratory pressure; PRVC, pressure-regulated volume control; ; SIMV, synchronized intermittent mandatory ventilation .

Tables

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  • Table 1

    Comparison of patient characteristics between FY 2017 and FY 2018 groups

    FY 2017FY 2018P value
    Patients (n)274245–
    Patient age years, mean±SD43.7±19.443.8±19.10.950
    Injury Severity Score20.0 (12.0–27.0)17.5 (10.0–29.0)0.352
    Ventilated days, median (25th–75th percentile)3.0 (3.0–9.0)3.0 (2.0–8.0)0.673
    Penetrating injury
    (vs. blunt)
    57 (20.8%)48 (19.6%)0.732
    Disposition  0.985
     Home86 (31.4%)78 (31.8%) 
     Rehab/skilled nursing facility110 (40.1%)101 (41.2%) 
     Died59 (21.5%)50 (20.4%) 
     Other19 (6.9%)16 (6.5%) 
    • FY, fiscal year; Rehab, Rehabilitation.

  • Table 2

    Comparison of VAE rates between FY 2017 and FY 2018 groups

    FY 2017FY 2018P value
    VAEs
     Patients (n)28110.014
     Rate per 1000 ventilator days14.617.130.039
    • FY, fiscal year; VAEs, ventilator-associated events.

  • Table 3

    Summary of logistic regression model predicting VAE

    P valueOR95% CI for OR
    Age0.2740.990.97 to 1.01
    ISS0.0291.031.00 to 1.06
    Penetrating injury0.6191.300.46 to 3.67
    Vented 7+days<0.00197.4713.08 to 726.65
    FY 2018 (Initial PEEP 6)0.0170.380.17 to 0.84
    • FY, fiscal year; ISS, Injury Severity Score; PEEP, positive end-expiratory pressure; VAE, ventilator-associated event.

  • Table 4

    Summary of logistic regression model predicting mortality

    FY 2017FY 2018
    P valueOR95% CI for ORP valueOR95% CI for OR
    Age<0.0011.051.03 to 1.07<0.0011.041.02 to 1.06
    ISS<0.0011.071.04 to 1.10<0.0011.071.04 to 1.10
    Mechanism of Injury0.9290.960.37 to 2.510.9860.990.33 to 3.02
    Presence of VAE0.0700.300.08 to 1.100.0028.772.22 to 34.61
    • FY, fiscal year; ISS, Injury Severity Score; VAE, ventilator-associated event.

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Minor change in initial PEEP setting decreases rates of ventilator-associated events in mechanically ventilated trauma patients
Ethan Ferrel, Kristina M Chapple, Liviu Gabriel Calugaru, Jennifer Maxwell, Jessica A Johnson, Andrew W Mezher, James N Bogert, Hahn Soe-Lin, Jordan A Weinberg
Trauma Surg Acute Care Open May 2020, 5 (1) e000455; DOI: 10.1136/tsaco-2020-000455

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Minor change in initial PEEP setting decreases rates of ventilator-associated events in mechanically ventilated trauma patients
Ethan Ferrel, Kristina M Chapple, Liviu Gabriel Calugaru, Jennifer Maxwell, Jessica A Johnson, Andrew W Mezher, James N Bogert, Hahn Soe-Lin, Jordan A Weinberg
Trauma Surg Acute Care Open May 2020, 5 (1) e000455; DOI: 10.1136/tsaco-2020-000455
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Minor change in initial PEEP setting decreases rates of ventilator-associated events in mechanically ventilated trauma patients
Ethan Ferrel, Kristina M Chapple, Liviu Gabriel Calugaru, Jennifer Maxwell, Jessica A Johnson, Andrew W Mezher, James N Bogert, Hahn Soe-Lin, Jordan A Weinberg
Trauma Surgery & Acute Care Open May 2020, 5 (1) e000455; DOI: 10.1136/tsaco-2020-000455
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