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Open Access

Relation between intra-abdominal pressure and early intestinal ischemia in rats

Steven G Strang, Ben van der Hoven, Kim Monkhorst, Samir Ali, Esther M M van Lieshout, Oscar J F van Waes, Michael H J Verhofstad
DOI: 10.1136/tsaco-2020-000595 Published 1 December 2020
Steven G Strang
1Trauma Research Unit, Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Ben van der Hoven
2Department of Intensive Care Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Kim Monkhorst
3Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Samir Ali
1Trauma Research Unit, Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Esther M M van Lieshout
1Trauma Research Unit, Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Oscar J F van Waes
1Trauma Research Unit, Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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Michael H J Verhofstad
1Trauma Research Unit, Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
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    Figure 1

    Effect of intra-arterial pressure (IAP) increase on temperature, mean arterial pressure and central venous pressure at 90 and 180 min. Temperature (A), mean arterial pressure (B) and central venous pressure (C) at 0, 90, and 180 min are demonstrated for the individual IAP groups and displayed as median with upper and lower limits. The Spearman correlation coefficient (Rs) and p value (p) represent correlation between IAP and the individual variables with corresponding statistical significance at 90 and 180 min.

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    Figure 2

    Effect of intra-arterial pressure (IAP) increase on arterial blood gas values at 90 and 180 min. pH (A), pO2 (B), pCO2 (C), bicarbonate (D), base deficit (E), and saturation (F) at 0, 90, and 180 min are demonstrated for the individual IAP groups and displayed as median with upper and lower limits. The Spearman correlation coefficient (Rs) and p value (p) represent correlation between IAP and the individual variables with corresponding statistical significance at 90 and 180 min.

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    Figure 3

    Effect of intra-arterial pressure (IAP) increase on serum lactate and albumin-cobalt binding at 90 and 180 min. ABSU, absorbance units; ACB, albumin-cobalt binding capacity. Lactate (A) and albumin-cobalt binding (B) at 0, 90, and 180 min are demonstrated for the individual groups and displayed as median with upper and lower limits. The Spearman correlation coefficient (Rs) and p value (p) represent correlation between IAP and the individual variables with corresponding statistical significance at 90 and 180 min.

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    Figure 4

    H&E sections of the least and most extensively damaged mucosa. In most sections of rats in all groups, no lesions were found in the small intestine (A). Grade 3 Parks/Chiu lesions of ischemia (ie, mucosal lifting down sides of the villi; see arrow) were seen sporadically (B).

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Relation between intra-abdominal pressure and early intestinal ischemia in rats
Steven G Strang, Ben van der Hoven, Kim Monkhorst, Samir Ali, Esther M M van Lieshout, Oscar J F van Waes, Michael H J Verhofstad
Trauma Surg Acute Care Open Dec 2020, 5 (1) e000595; DOI: 10.1136/tsaco-2020-000595

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Relation between intra-abdominal pressure and early intestinal ischemia in rats
Steven G Strang, Ben van der Hoven, Kim Monkhorst, Samir Ali, Esther M M van Lieshout, Oscar J F van Waes, Michael H J Verhofstad
Trauma Surg Acute Care Open Dec 2020, 5 (1) e000595; DOI: 10.1136/tsaco-2020-000595
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Relation between intra-abdominal pressure and early intestinal ischemia in rats
Steven G Strang, Ben van der Hoven, Kim Monkhorst, Samir Ali, Esther M M van Lieshout, Oscar J F van Waes, Michael H J Verhofstad
Trauma Surgery & Acute Care Open Dec 2020, 5 (1) e000595; DOI: 10.1136/tsaco-2020-000595
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