@article {Khane000483, author = {Abid D Khan and Anna J Elseth and Jacqueline A Brosius and Eliza Moskowitz and Sean C Liebscher and Michael J Anstadt and Julie A Dunn and John H McVicker and Thomas Schroeppel and Richard P Gonzalez}, title = {Multicenter assessment of the Brain Injury Guidelines and a proposal of guideline modifications}, volume = {5}, number = {1}, elocation-id = {e000483}, year = {2020}, doi = {10.1136/tsaco-2020-000483}, publisher = {BMJ Specialist Journals}, abstract = {Background The Brain Injury Guidelines provide an algorithm fortreating patients with traumatic brain injury (TBI) and intracranial hemorrhage(ICH) that does not mandate hospital admission, repeat head CT, orneurosurgical consult for all patients. The purposes of this study are toreview the guidelines{\textquoteright} safety, to assess resource utilization, and to proposeguideline modifications that improve patient safety and widespreadreproducibility.Methods A multi-institutional review of TBI patients was conducted. Patients with ICH on CT were classified as BIG 1, 2, or 3 based on the guidelines. BIG 3 patients were excluded. Variables collected included demographics, Injury Severity Score (ISS), hospital length of stay (LOS), intensive care unit LOS, number of head CTs, type of injury, progression of injury, and neurosurgical interventions performed.Results 269 patients met inclusion criteria. 98 were classifiedas BIG 1 and 171 as BIG 2. The median length of stay (LOS) was 2 (2,4)days and the ICU LOS was 1 (0,2) days. Most patients had a neurosurgeryconsultation (95.9\%) and all patients included had a repeat head CT. 370repeat head CT scans were performed, representing 1.38 repeat scans perpatient. 11.2\% of BIG 1 and 11.1\% of BIG 2 patients demonstratedworsening on repeat head CT. Patients who progressed exhibited a higherISS (14 vs. 10, p=0.040), and had a longer length of stay (4 vs. 2 days;p=0.015). After adjusting for other variables, the presence of epiduralhematoma (EDH) and intraparenchymal hematoma were independent predictors ofprogression. Two BIG 2 patients with EDH had clinical deteriorationrequiring intervention.Discussion The Brain Injury Guidelines may improve resourceallocation if utilized, but alterations are required to ensure patientsafety. The modified Brain Injury Guidelines refine the originalguidelines to enhance reproducibility and patient safety while continuing toprovide improved resource utilization in TBI management.}, URL = {http://tsaco.smart01.highwire.org/content/5/1/e000483}, eprint = {http://tsaco.smart01.highwire.org/content/5/1/e000483.full.pdf}, journal = {Trauma Surgery \& Acute Care Open} }