Characteristic of direct oral anticoagulant agents
| Dabigatran | Rivaroxaban | Apixaban | |
|---|---|---|---|
| Mechanism of action | Thrombin inhibitor | Factor Xa inhibitor | Factor Xa inhibitor |
| T1/2 (hours) | 12–14 | 9–13 | 8–15 |
| Regimen | BID | QID | BID |
| Time to peak (hours) | 1 | 2–4 | 3 |
| Renal excretion | 80% | 40% | 25% |
| Metabolism and uptake | P-glycoprotein | CY3A4 and P-glycoprotein | CY3A4 and P-glycoprotein |
BID, twice daily; QID, four times a day.