Serum | Period | ||||
---|---|---|---|---|---|
Group | Baseline | Shock30 | T30 | T60 | T120 |
Na (mEq/L) | |||||
Sham | 145±3.1 | 149±5.9 | 144±4.7 | 154±9.2 | 135±10.50 |
Shock-only | 138±1.2 | 141±5.3 | 140±5.7 | 132±4.3b | 154±0.00 |
Shock+LRS | 136±2.1 | 132±1.8a | 131±2.2 | 131±1.2c | 130±4.70 |
Shock+Terli | 138±2.4 | 134±2.9a | 138±2.7 | 134±1.5c | 127±2.90 |
K (mEq/L) | |||||
Sham | 4.6±0.3 | 4.7±0.2 | 4.6±0.2 | 5.1±0.3 | 4.8±0.10 |
Shock-only | 4.8±0.2 | 5.9±0.4a | 6.4±0.5b | 6.0±0.9 | 7.7±0.00 |
Shock+LRS | 4.2±0.1 | 6.4±0.4a | 4.5±0.2f | 5.1±0.1 | 5.9±0.30 |
Shock+Terli | 4.3±0.1 | 5.3±0.2g | 5.4±0.2d | 5.4±0.2 | 5.6±0.40 |
Cl (mEq/L) | |||||
Sham | 108±2.1 | 111±4.6 | 109±4.4 | 115±7.7 | 104±15.5 |
Shock-only | 105±2.4 | 107±4.3 | 106±4.7 | 107±5.2 | 117±0.0 |
Shock+LRS | 100±1.6 | 100±1.7 | 94±4.7 | 99±1.0a | 94±4.60 |
Shock+Terli | 104±2.2 | 99±2.2 | 102±2.1 | 96±3.1b | 91±3.20 |
Mg (mg/dL) | |||||
Sham | 1.9±0.14 | 1.7±0.10 | 1.7±0.10 | 1.7±0.14 | 1.8±0.10 |
Shock-only | 1.8±0.08 | 2.1±0.08 | 2.2±0.11a | 2.1±0.17 | 2.8±0.00 |
Shock+LRS | 1.8±0.10 | 2.3±0.13 | 1.5±0.08f | 1.5±0.09d | 1.7±0.12 |
Shock+Terli | 1.9±0.07 | 2.1±0.12 | 1.9±0.09h | 2.1±0.10h | 2.0±0.22 |
P (mg/dL) | |||||
Sham | 9.3±1.00 | 9.4±0.91 | 9.7±0.74 | 9.9±0.91 | 10±2.00 |
Shock-only | 8.8±0.52 | 10.6±0.59 | 12.2±0.91a | 10.7±1.00 | 13±0.00 |
Shock+LRS | 9.3±0.48 | 12.2±0.85 | 8.1±0.42f | 8.3±0.51 | 9.7±0.90 |
Shock+Terli | 8.5±0.40 | 10.1±0.56 | 10.8±0.47d | 12.0±0.55h | 11.6±1.8 |
Urea (mg/dL) | |||||
Sham | 20.2±2.33 | 21.8±2.31 | 23.1±2.93 | 23.5±2.56 | 17.0±2.00 |
Shock-only | 20.4±2.33 | 25.4±2.45 | 27.4±2.25 | 24.0±0.45 | 31.0±0.00 |
Shock+LRS | 19.1±2.01 | 25.0±2.43 | 21.3±2.01 | 33.6±11.46 | 26.0±4.00 |
Shock+Terli | 26.5±2.76 | 33.0±3.10 | 35.1±3.22a,h | 37.2±3.20 | 41.1±5.10 |
Urine | Period | ||||
---|---|---|---|---|---|
Group | Baseline | Shock30 | T30 | T60 | T120 |
UNaV (mEq/period) | |||||
Sham | 0.5±0.1 | 1.2±0.7 | 0.6±0.3 | 0.6±0.2 | 0.8±0.3 |
Shock-only | 0.7±0.1 | 0.6±0.3 | 0.2±0.1 | 0.2±0.1 | 0 |
Shock+LRS | 0.4±0.1 | 0.4±0.2 | 20.5±4.7c,e | 2.2±0.8 | 0.1±0.0 |
Shock+Terli | 0.5±0.1 | 0.2±0.1 | 0.2±0.0i | 0.5±0.3 | 0.3±0.1 |
UKV (mEq/period) | |||||
Sham | 1.8±0.5 | 4.5±1.4 | 2.7±0.8 | 2.7±0.5 | 2.6±1.7 |
Shock-only | 3.7±1.1 | 1.5±0.4a | 0.2±0.1 | 0.1±0.0a | 0 |
Shock+LRS | 1.9±0.3 | 1.8±0.3a | 12.7±5.7c,f | 2.3±0.6d | 0.6±0.2 |
Shock+Terli | 2.2±0.3 | 1.8±0.8a | 0.8±0.2h | 0.9±0.3 | 1.5±0.7 |
UClV (mEq/period) | |||||
Sham | 2.2±1.2 | 4.3±1.7 | 1.9±0.5 | 1.7±0.3 | 1.5±0.8 |
Shock-only | 3.9±0.9 | 1.6±0.4 | 0.3±0.2 | 0.2±0.1 | 0 |
Shock+LRS | 1.5±0.3 | 1.4±0.4 | 19.5±4.9b,e | 3.7±1.3 | 0.4±0.2 |
Shock+Terli | 2.7±0.6 | 1.3±0.6 | 0.6±0.2i | 0.6±0.2 | 1.1±0.5 |
UMgV (mg/period) | |||||
Sham | 3.2±1.3 | 1.8±0.4 | 1.5±0.9 | 1.2±0.4 | 0.7±0.5 |
Shock-only | 6.3±1.5 | 1.2±0.2 | 0.1±0.4 | 0.3±0.1 | 0 |
Shock+LRS | 3.7±0.7 | 2.2±0.6 | 9.1±1.6b,f | 2.2±0.7 | 0.4±0.2 |
Shock+Terli | 5.2±0.9 | 1.6±0.5 | 2.6±1.0i | 2.0±0.6 | 3.3±0.8 |
UPV (mg/period) | |||||
Sham | 1.7±1.4 | 11.3±6.3 | 7.4±3.8 | 7.9±3.3 | 3.2±1.6 |
Shock-only | 4.3±2.3 | 4.7±2.1 | 1.2±0.8 | 0.2±0.2 | 0 |
Shock+LRS | 1.9±1.2 | 7.8±2.5 | 74.1±20.8b,d | 14±4.6d | 3.8±3.0 |
Shock+Terli | 3.3±1.6 | 2.4±1.4 | 6.1±3.04h | 7.4±3.3 | 14.2±12.2 |
UureaV (mg/period) | |||||
Sham | 184.4±49.3 | 371.8±88.1 | 223.8±66.6 | 210.4±43.4 | 162.9±113.1 |
Shock-only | 489.5±82.9 | 117±22.9a | 18.3±7.9 | 15.5±2.2a | 0 |
Shock+LRS | 203.7±31.1 | 140.9±280.6a | 468.5±98.8a,e | 193.4±48.6d | 64.6±28.2 |
Shock+Terli | 428.3±94.3 | 194.9±77.8 | 103.3±24.4i | 87.6±27.9 | 282.6±103.6 |
Uosm (mOsm/kg) | |||||
Sham | 735.8±96.1 | 748.7±102.3 | 739±85.7 | 734.6±90.6 | 617.5±59.5 |
Shock-only | 563.4±95.7 | 592.6±65.5 | 446.5±154.5a | 541.3±92.2 | 793±0.0 |
Shock+LRS | 621.0±39.6 | 629.3±37.3 | 368.6±15.5c | 464.7±27.8b | 462.8±25.5 |
Shock+Terli | 659.0±46.8 | 693.5±45.9 | 593.4±54.4b | 522±39.5a | 653±91.2 |
Values are mean±SE.
ap<0.05 vs sham; bp<0.01 vs sham; cp<0.001 vs sham; dp<0.05 vs shock-only; ep<0.01 vs shock-only; fp<0.001 vs shock-only; gp<0.05 vs shock+LRS; hp<0.01 vs shock+LR; ip<0.001 vs shock+LRS.
Sham, anesthetized but not subjected to hemorrhagic shock; Shock+LRS, subjected to hemorrhagic shock and subsequently treated with LRS at a volume equal to three times that of the blood removed; Shock+Terli, subjected to hemorrhagic shock and subsequently treated with a 2 mg bolus of terlipressin; Shock30, 30 min after achieving the target MAP (immediately prior to treatment); Shock-only, subjected to hemorrhagic shock and left untreated; T120, 120 min after treatment; T30, 30 min after treatment; T60, 60 min after treatment; UClV, urinary excretion of chloride; UKV, urinary excretion of potassium; UMgV, urinary excretion of magnesium; UNaV, urinary excretion of sodium; Uosm, urine osmolality; UureaV, urinary excretion of urea.