Patient baseline characteristics, treatments, and outcomes
| Intervention | P value | ||
| FFP (n=25) | PCC (n=27) | ||
| Age* | 83.8 (6.51) | 85.8 (7.10) | 0.290 |
| Number of females (%)† | 16 (64) | 10 (37) | 0.096 |
| Number of white patients (%)† | 22 (88) | 27 (100) | 0.208 |
| Congestive heart failure† | 1 (4) | 3 (11) | 0.336 |
| History of falls (%)† | 9 (36.0) | 11 (40.7) | 0.725 |
| Glasgow Coma Scale (SD)* | 14.32 (2.44) | 14.04 (2.70) | 0.693 |
| Injury Severity Score (SD)* | 15.72 (4.08) | 16.93 (5.57) | 0.375 |
| AIS-Head and Neck (SD)* | 3.64 (0.70) | 3.85 (0.72) | 0.287 |
| Initial scan | |||
| Subdural hematoma (%) | 14 (56) | 21 (78) | |
| Subarachnoid hemorrhage | 6 (24) | 2 (7) | |
| Intraparenchymal hemorrhage (%) | 4 (16) | 7 (26) | |
| Infusion volume, mL (SD)* | 910 (370) | 87 (33) | <0.001‡ |
| Neurointervention (%)† | 2 (8.0) | 3 (11.1) | 0.704 |
| Mortality (%)* | 0 (0.0) | 3 (11.1) | 0.262 |
| Hospital LOS, days (SD)* | 4.16 (2.56) | 3.73 (1.42) | 0.335 |
| Admitted to ICU (%)† | 17 (68) | 21 (78) | 0.630 |
| ICU LOS, days (SD)* | 2.29 (1.16) | 2.43 (0.68) | 0.676 |
| Proportion that reached INR <1.5 within 8 hours (%)† | 4/14 (29) | 17/21 (81) | 0.002‡ |
| CT progression within 24 hours (%)† | 5/14 (36) | 10/23 (43) | 0.365 |
*Pearson’s χ2 test.
†Two-sample t-test assuming equal variance.
‡Significant result
AIS, Abbreviated Injury Scale; FFP, fresh frozen plasma; ICU, intensive care unit; INR, international normalized ratio; LOS, length of stay; PCC, prothrombin complex concentrate.