Senior author | Year | Design | n | Inclusion | Parameter(s) | Sampling timing | Primary outcome | Conclusion |
Nelson DR24 | 2005 | Prospective | 840 | Severe sepsis | PT, AT, D-dimer, APC, SOFA | Diagnosis | 28-day mortality | Coagulopathy the first day after diagnosis predicts worse 28-day mortality. |
Angus DC67 | 2011 | Multicenter cohort | 893 | Community Acquired Pneumonia | AT, factor IX, TAT, PAI-1, D-dimer | Admission, weekly until discharge | All-cause, cardiovascular, 1-year mortality | Elevated TAT and D-dimer within 96 hours of discharge predict cardiovascular death. |
Gothot A42 | 2012 | Prospective cohort | 39 | Septic shock | 17 coagulopathy markers | Admission through day 7 | Inpatient, 90-day mortality | Thrombin generation deficit is associated with greater 90-day mortality. |
Jones AE64 | 2014 | Systematic review | – | – | DIC/coagulopathy | >28 days | Organ-specific outcomes | Variable rates of coagulopathy and resolution 1 month after severe sepsis. |
Sakata Y66 | 2014 | Prospective | 37 | Sepsis without DIC at baseline | 14 coagulopathy markers | Admission | DIC development, 28-day mortality | TAT and PAI-1 predict 28-day mortality. |
Jones AE65 | 2016 | Retrospective | 110 | Severe sepsis/shock | INR >1.5 Platelets <100 000/µL | Admission, 28–90 days, and >90 days | Organ dysfunction | INR >1.5 is associated with organ dysfunction at 28–90 days. |
Mebazaa A72 | 2018 | Multicenter prospective | 1570 | Critical illness ICU survivors | Platelets <100 000/µL | Discharge | All-cause 1-year mortality | Low platelets at discharge are associated with greater risk 1-year mortality. |
APC, activated protein C; DIC, disseminated intravascular coagulopathy; ICU, intensive care unit; INR, international normalized ratio; PAI-1, plasminogen activator inhibitor-1; PT, prothrombin time; SOFA, Sequential Organ Failure Assessment; TAT, thrombin-antithrombin complex.