Table 2

Model estimation coefficients for markers at T0—YOUNG vs OLD plasma age

Plasma group (n=137)					ISS >30 plasma subgroup (n=56)
Marker	Coefficient	95% CI		P value	Coefficient	95% CI		P value
Marker	Coefficient	Lower limit	Upper limit	P value	Coefficient	Lower limit	Upper limit	P value
IL-1b	0.456	−2.762	3.673	0.781	4.394	1.027	7.761	0.011
IL-2	0.064	−1.791	1.919	0.946	2.414	0.262	4.565	0.028
IL-4	−20.063	−66.499	26.373	0.397	39.6	13.482	65.718	0.003
IL-5	−2.664	−8.369	3.041	0.36	2.667	0.921	4.413	0.003
IL-6	35.696	−158.755	230.147	0.719	7.664	−384.257	399.586	0.969
IL-7	4.116	−2.281	10.513	0.207	11.494	−0.96	23.947	0.07
IL-8	6.21	−11.606	24.026	0.494	−28.604	−86.985	29.776	0.337
IL-9	2.725	−18.023	23.473	0.797	25.238	2.171	48.304	0.032
IL-10	60.645	−102.332	223.622	0.466	−19.358	−285.774	247.058	0.887
IL-17a	1.457	−3.876	6.79	0.592	6.27	0.1	12.439	0.046
IL-17e	69.021	−38.997	177.039	0.21	308.579	103.895	513.264	0.003
IL-21	9.08	−22.34	40.5	0.571	47.905	11.959	83.852	0.009
IL-22	104.23	−248.61	457.071	0.563	715.174	165.919	1264.429	0.011
IL-23	1.042	−6.305	8.39	0.781	12.725	5.139	20.311	0.001
IL-27	51.292	−453.426	556.009	0.842	977.828	137.887	1817.769	0.023
IL-33	10.925	−39.263	61.112	0.67	95.05	32.919	157.18	0.003
GM-CSF	−7.832	−20.563	4.9	0.228	14.629	5.478	23.78	0.002
MCP-1	366.455	−29.438	762.349	0.07	−28.592	−912.995	855.811	0.949
MIG	4285.834	−3033.508	11 605.176	0.251	14 107.398	−9169.341	37 384.137	0.235
TNF-α	0.964	−11.013	12.94	0.875	5.174	−28.073	38.421	0.76
Adiponectin	−1736.773	−3848.6	375.055	0.107	−355.837	−2733.742	2022.067	0.769
hcDNA	−8.264	−18.546	2.017	0.115	−34.837	−49.677	−19.998	0
S100A10	−0.717	−2.027	0.593	0.284	−0.892	−2.003	0.218	0.115
suPAR	−0.374	−0.924	0.177	0.183	0.351	−0.64	1.343	0.487
Syndecan-1	2.035	−23.878	27.949	0.878	−54.767	−96.663	−12.872	0.01
TM	0.103	−1.204	1.41	0.877	0.92	−1.079	2.919	0.367
VEGF	81.405	−103.409	266.218	0.388	2.333	−276.162	280.829	0.987

GM-CSF, granulocyte-macrophage colony-stimulating factor; hcDNA, histone-complexed DNA; IL, interleukin; ISS, Injury Severity Score; MCP-1, monocyte chemoattractant protein; MIG, INF-gamma; S100A10, human S100 calcium-binding protein A10; suPAR, soluble urokinase receptor; TM, thrombomodulin; TNF-α, tumor necrosing factor-α; VEGF, vascular endothelial growth factor.