Table 1

Gene ontology (GO) biologic processes significantly enriched after valproic acid treatment

GO term# proteins (DE/all)P value
Low-density lipoprotein particle clearance6/90.002
ATP hydrolysis coupled cation transmembrane transport9/190.003
SRP-dependent cotranslational protein targeting to membrane10/240.005
Viral transcription10/240.005
Ephrin receptor signaling pathway7/150.009
Membrane organization31/1120.01
Regulation of hormone secretion9/30.012
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger9/170.018
Response to insulin11/330.021
Generation of precursor metabolites and energy30/1100.026
Nuclear-transcribed mRNA catabolic process10/300.028
Mitochondrion organization20/750.03
Retrograde vesicle-mediated transport, Golgi to Endoplasmic Reticulum (ER)5/110.031
Regulation of neurotransmitter transport10/190.033
Regulation of nucleotide metabolic process6/150.036
Antigen processing and presentation7/190.037
Dendrite morphogenesis7/190.037
Monovalent inorganic cation transport16/580.038
Cellular response to hormone stimulus19/640.04
Metal ion transport20/770.04
ATP metabolic process19/730.044
Regulation of dendrite development5/120.046
Regulation of peptidyl-tyrosine phosphorylation6/160.049
Tricarboxylic acid cycle7/200.049
  • # proteins are the number of proteins differentially expressed in this proteomic data set out of the total number of proteins that contribute to that GO term.

  • P value represents the corrected p value after Elim pruning.