Baseline characteristics and univariate analysis of the development and validation cohorts
| Development cohort (n=308) | |||
| Factor | Delirium (n=91) | No delirium (n=217) | P value |
| Age | 77 (65–83) | 58 (38–70) | <0.0001 |
| Sex, male (%) | 54 (59.3) | 158 (72.8) | 0.0224 |
| BMI | 21.1 (17.9–23.5) | 22.6 (20.2–25.1) | <0.0001 |
| Clinical Frailty Score | 4 (3–4) | 3 (2–3) | <0.0001 |
| Charlson index | 0 (0–2) | 0 (0–1) | <0.0001 |
| Smoking (%) | 16 (17.6) | 84 (38.7) | 0.0003 |
| Alcohol consumption (%) | 35 (38.4) | 117 (53.9) | 0.0174 |
| Dementia (%) | 12 (13.2) | 2 (0.922) | <0.0001 |
| Systolic blood pressure | 137 (111–160) | 141 (123–156) | 0.1641 |
| GCS score | 14 (13–15) | 15 (14–15) | <0.0001 |
| Heart rate | 84 (71–100) | 80 (70–92) | 0.00393 |
| BT (°C) | 36.3 (36–36.8) | 36.5 (36.1–36.9) | 0.0212 |
| Hemoglobin | 121 (105–137) | 137 (124–150) | <0.0001 |
| Fibrinogen | 259 (226–335) | 257 (210–305) | 0.2482 |
| FDP | 60 (25.6–141) | 16.7 (7–47.5) | <0.0001 |
| Lactate | 2.3 (1.5–4) | 2.1 (1.6–2.9) | 0.1775 |
| CRP | 0.09 (0.03–0.4) | 0.05 (0.02–0.14) | 0.0012 |
| RTS | 7.84 (7.26–7.84) | 7.84 (7.84–7.84) | 0.0004 |
| ISS | 17 (10–26) | 12 (9–19) | 0.0002 |
| TBI (%) | 37 (57.8) | 27 (42.2) | <0.0001 |
| Validation cohort (n=206) | |||
| Factor | Delirium (n=46) | No delirium (n=160) | P value |
| Age | 77 (63–85) | 64 (42–75) | <0.0001 |
| Sex, male (%) | 28 (60.9) | 112 (70.0) | 0.2827 |
| BMI | 21.1 (18.9–23.7) | 22.6 (20.0–25.2) | 0.0409 |
| Clinical Frailty Score | 4 (3–5) | 3 (2–4) | <0.0001 |
| Charlson index | 1 (0–1) | 0 (0–1) | 0.0220 |
| Smoking (%) | 12 (26.1) | 55 (34.3) | 0.3723 |
| Alcohol consumption (%) | 19 (41.3) | 80 (50.0) | 0.3195 |
| Dementia (%) | 12 (26.1) | 5 (3.1) | <0.0001 |
| Systolic blood pressure | 139 (113–160) | 140 (120–164) | 0.1247 |
| GCS score | 14 (13–15) | 15 (14–15) | <0.0001 |
| Heart rate | 82 (75–102) | 79 (69–93) | 0.0481 |
| BT (°C) | 36.4 (36–36.8) | 36.6 (36.2–37) | 0.0441 |
| Hemoglobin | 12.2 (10.3–13.9) | 13.7 (12.2–15) | <0.0001 |
| Fibrinogen | 276 (191–321) | 259 (220–308) | 0.8751 |
| FDP | 76.5 (22–120) | 20.9 (6.2–47) | <0.0001 |
| Lactate | 2.5 (1.7–3.4) | 1.8 (1.4–2.7) | 0.0081 |
| CRP | 0.08 (0.02–0.34) | 0.04 (0.02–0.12) | 0.0784 |
| RTS | 7.84 (7.55–7.84) | 7.84 (7.84–7.84) | <0.0001 |
| ISS | 17 (10–25) | 14 (9–19) | 0.0408 |
| TBI (%) | 16 (34.8) | 35 (21.9) | 0.0831 |
Values are mean (quarter value) or frequency (%).
BMI, body mass index; BT, body temperature; CRP, C-reactive protein; FDP, fibrin/fibrinogen degradation products; GCS, Glasgow Coma Scale; ISS, Injury Severity Score; RTS, Revised Trauma Score; TBI, traumatic brain injury.