Performing delayed anastomosis (11) | Postponing delayed anastomosis (10) | P value* | |
Age (years) | 52.0±20.3 | 64.2±16.3 | 0.0977 |
Cause of surgery | 0.0967 | ||
Trauma | 10 | 6 | |
Lower gastrointestinal perforation | 1 | 4 | |
Injury Severity Score | 24.3±10.6 | 31.5±8.6 | 0.1585 |
APACHE Ⅱ score | 21.2±5.0 | 29.1±5.3 | 0.0066 |
Duration of initial surgery (min) | 99.3±20.9 | 119.4±38.3 | 0.2597 |
Bleeding during initial surgery (mL) | 2539.4±2319.1 | 2024.1±2564.1 | 0.4386 |
48 hours after initial surgery | |||
pH | 7.39±0.06 | 7.38±0.04 | 0.9719 |
Base excess (mmol/L) | 2.09±2.64 | –0.83±3.71 | 0.0725 |
INR | 1.22±0.21 | 1.46±0.19 | 0.0136 |
Alb (g/dL) | 2.49±0.54 | 2.27±0.38 | 0.2016 |
Cre (mg/dL) | 0.87±0.31 | 1.39±0.97 | 0.2448 |
P/F ratio | 420.5±120.7 | 276.0±106.2 | 0.0112 |
CRP (mg/dL) | 9.44±7.34 | 14.89±7.35 | 0.0448 |
Up to 48 hours after the initial surgery | |||
Total crystalloid administration (mL) | 10407.0±4359.2 | 14787.9±5483.3 | 0.0783 |
Total NPWT output (mL) | 959.0±460.3 | 1482.0±666.8 | 0.024 |
Total urine output (mL) | 4040.6±1958.9 | 2318.1±1182.0 | 0.0317 |
Sites of anastomosis | |||
Small intestine–small intestine | 3 | 3 | |
Small intestine–colon | 4 | 1 | |
Colon–colon | 4 | 4 | |
Colon–rectal | – | 2 | |
Time until anastomosis (min) | 46.4±2.8 | 102.1±43.7 | 0.0006 |
OA duration (day) | 2.1±0.3 | 5.9±4.0 | 0.0002 |
Vasopressor infusion | 3 (27%) | 5 (50%) | 0.2841 |
Alb administration | 9 (81%) | 6 (60%) | 0.269 |
Renal replacement therapy | 1 (9%) | 6 (60%) | 0.0134 |
PMX-DHP | 1 (9%) | 5 (50%) | 0.0382 |
Postoperative complications | |||
Surgical site infection | 3 (27%) | 7 (70%) | 0.0502 |
Adhesive intestinal obstruction | 2 (18%) | 0 (0%) | 0.1563 |
Anastomotic leak | 0 (0%) | 1 (10%) | 0.2825 |
Data presented as mean±SD or number of patients with percentage.
*Wilcoxon rank-sum test or Χ2 test.
Alb, albumin; APACHE Ⅱ, Acute Physiology and Chronic Health Evaluation Ⅱ; Cre, creatinine; CRP, C-reactive protein; FiO2, fractional inspired oxygen; INR, international normalized ratio; NPWT, negative-pressure wound therapy; OA, open abdomen; PaO2, arterial oxygen pressure; P/F, PaO2/FiO2; PMX-DHP, direct hemoperfusion with polymyxin B-immobilized fiber.