Papers presentedThe effects of preinjury clopidogrel use on older trauma patients with head injuries
Section snippets
Methods
After obtaining institutional review board approval, a retrospective chart review was performed on all patients greater than 50 years of age who presented to a level 2 trauma center between January 1, 2002, and August 31, 2005. The charts of those patients who had documented preinjury use of clopidogrel were further reviewed. A control group of patients with no history of clopidogrel use was randomly matched for age, sex, mechanism of injury, and Injury Severity Score (ISS). The types of
Results
During this time period, there were a total of 5,875 trauma patients admitted, of which there were 1,020 trauma patients ≥50 years of age. Forty-three patients had documented preinjury clopidogrel use (P). A control group (C) from the patients without previous clopidogrel use was matched based on previously mentioned criteria. Gender (58% male) and age (average age, 73) were similar between the 2 groups. The most common mechanisms of injury in the majority of patients were fall and motor
Comments
Clopidogrel is an antiplatelet medication that inhibits adenosine diphosphate–induced platelet aggregation. It is indicated for patients with recent myocardial infarction, recent stroke, established peripheral arterial disease, and acute coronary syndrome. Because of its reported benefits in decreasing the morbidity of thrombotic events in patients with these conditions, its use has increased over the past several years especially in patients >65 years of age and in patients with coronary
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