The evolutionary success of an organism is a testament to its inherent capacity to keep pace
with environmental conditions that change over short and long periods. Mechanisms …

The Sc2.0 project is building a eukaryotic synthetic genome from scratch. A major milestone
has been achieved with all individual Sc2.0 chromosomes assembled. Here, we describe …

Here, we report the design, construction, and characterization of a tRNA neochromosome, a
designer chromosome that functions as an additional, de novo counterpart to the native …

Living organisms persist by virtue of complex interactions among many components organized
into dynamic, environment-responsive networks that span multiple scales and dimensions…

Sequence features of genes and their flanking regulatory regions are determinants of RNA
transcript isoform expression and have been used as context-independent plug-and-play …

Microbes can tailor transcriptional responses to diverse environmental challenges despite
having streamlined genomes and a limited number of regulators. Here, we present data‐…

An over-the-road study of visual–manual destination entry using an example original
equipment GPS-based navigation system was accomplished in traffic on urban streets and …

Microbes are diverse and extremely versatile organisms that play vital roles in all ecological
niches. Understanding and harnessing microbial systems will be key to the sustainability of …

Deep mutational scanning is a powerful approach to investigate a wide variety of research
questions including protein function and stability. Here, we perform deep mutational scanning …

There is an urgent need for strategies to discover secondary drugs to prevent or disrupt
antimicrobial resistance (AMR), which is causing >700,000 deaths annually. Here, we …