User profiles for Aaron Brooks
Aaron N. BrooksGenetic Design Group Lead @ Ginkgo Bioworks Verified email at ginkgobioworks.com Cited by 590 |
Adaptation of cells to new environments
The evolutionary success of an organism is a testament to its inherent capacity to keep pace
with environmental conditions that change over short and long periods. Mechanisms …
with environmental conditions that change over short and long periods. Mechanisms …
[PDF][PDF] Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
…, AL Hughes, L Lazar-Stefanita, S Yang, AN Brooks… - Cell, 2023 - cell.com
The Sc2.0 project is building a eukaryotic synthetic genome from scratch. A major milestone
has been achieved with all individual Sc2.0 chromosomes assembled. Here, we describe …
has been achieved with all individual Sc2.0 chromosomes assembled. Here, we describe …
[PDF][PDF] Design, construction, and functional characterization of a tRNA neochromosome in yeast
Here, we report the design, construction, and characterization of a tRNA neochromosome, a
designer chromosome that functions as an additional, de novo counterpart to the native …
designer chromosome that functions as an additional, de novo counterpart to the native …
[HTML][HTML] Macromolecular networks and intelligence in microorganisms
Living organisms persist by virtue of complex interactions among many components organized
into dynamic, environment-responsive networks that span multiple scales and dimensions…
into dynamic, environment-responsive networks that span multiple scales and dimensions…
Transcriptional neighborhoods regulate transcript isoform lengths and expression levels
AN Brooks, AL Hughes, S Clauder-Münster, LA Mitchell… - Science, 2022 - science.org
Sequence features of genes and their flanking regulatory regions are determinants of RNA
transcript isoform expression and have been used as context-independent plug-and-play …
transcript isoform expression and have been used as context-independent plug-and-play …
A system‐level model for the microbial regulatory genome
Microbes can tailor transcriptional responses to diverse environmental challenges despite
having streamlined genomes and a limited number of regulators. Here, we present data‐…
having streamlined genomes and a limited number of regulators. Here, we present data‐…
On the highway measures of driver glance behavior with an example automobile navigation system
DP Chiang, AM Brooks, DH Weir - Applied ergonomics, 2004 - Elsevier
An over-the-road study of visual–manual destination entry using an example original
equipment GPS-based navigation system was accomplished in traffic on urban streets and …
equipment GPS-based navigation system was accomplished in traffic on urban streets and …
[HTML][HTML] Data-driven integration of genome-scale regulatory and metabolic network models
Microbes are diverse and extremely versatile organisms that play vital roles in all ecological
niches. Understanding and harnessing microbial systems will be key to the sustainability of …
niches. Understanding and harnessing microbial systems will be key to the sustainability of …
[HTML][HTML] Deep mutational scanning of essential bacterial proteins can guide antibiotic development
L Dewachter, AN Brooks, K Noon, C Cialek… - nature …, 2023 - nature.com
Deep mutational scanning is a powerful approach to investigate a wide variety of research
questions including protein function and stability. Here, we perform deep mutational scanning …
questions including protein function and stability. Here, we perform deep mutational scanning …
Disrupting the ArcA regulatory network amplifies the fitness cost of tetracycline resistance in Escherichia coli
…, V Srinivas, A Dash, SRC Immanuel, AN Brooks… - Msystems, 2023 - Am Soc Microbiol
There is an urgent need for strategies to discover secondary drugs to prevent or disrupt
antimicrobial resistance (AMR), which is causing >700,000 deaths annually. Here, we …
antimicrobial resistance (AMR), which is causing >700,000 deaths annually. Here, we …