… Kenneth Rockwood, Chris MacKnight, David Hogan and Howard Bergman examined
patients. Ian McDowell, Chris MacKnight and David Hogan commented on and revised interim …

Between 1977 and 1984, 48 girls but only 26 boys were born to parents exposed to 2, 3, 7,
8 tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) in Seveso, Italy. 1 The 1976 industrial …

Background. Frailty and fitness are important attributes of older persons, but population
samples of their prevalence, attributes, and outcomes are limited. Methods. The authors report …

Background Recent reports suggest a possibly protective effect for statins in patients with
Alzheimer disease. This association could be due to indication bias, ie, people who elect to …

Background: In addition to nonmodifiable genetic risk factors, potentially modifiable factors
such as hypertension, hyperlipidemia and environmental exposures have been identified as …

Background: Conflicting results have been reported about the status of diabetes mellitus as
a risk for Alzheimer’s disease. We investigated the relationship between diabetes and …

The use of the term ‘frailty’ has shown tremendous growth in the last 15 years, but this has
not been accompanied by a widely accepted definition, let alone agreed-upon measures. In …

In a representative Canadian population survey (n=66 589) the proportion of accumulated
deficits in a frailty index showed a linear relationship with mortality in a log–log plot, such that …

This paper extends a method of apprising health status to a broad range of ages from
adolescence to old age. The “frailty index” is based on the accumulation of deficits (symptoms, …

The recognition that cognitive impairment of vascular origin is not limited to multi-infarct
dementia has led to the development of several sets of new criteria for vascular dementia (VaD). …