[HTML][HTML] Machine learning applications in solid organ transplantation and related complications
The complexity of transplant medicine pushes the boundaries of innate, human reasoning.
From networks of immune modulators to dynamic pharmacokinetics to variable postoperative …
From networks of immune modulators to dynamic pharmacokinetics to variable postoperative …
[HTML][HTML] c-Met signaling in the development of tumorigenesis and chemoresistance: potential applications in pancreatic cancer
D Delitto, E Vertes-George, SJ Hughes… - World journal of …, 2014 - ncbi.nlm.nih.gov
Pancreatic ductal adenocarcinoma is the 4 th leading cause of cancer deaths in the United
States. The majority of patients are candidates only for palliative chemotherapy, which has …
States. The majority of patients are candidates only for palliative chemotherapy, which has …
Targeting tumor tolerance: A new hope for pancreatic cancer therapy?
D Delitto, SM Wallet, SJ Hughes - Pharmacology & therapeutics, 2016 - Elsevier
With a 5-year survival rate of just 8%, pancreatic cancer (PC) is projected to be the second
leading cause of cancer deaths by 2030. Most PC patients are not eligible for surgery with …
leading cause of cancer deaths by 2030. Most PC patients are not eligible for surgery with …
[PDF][PDF] Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin
Cancer-associated fibroblasts (CAFs) are integral to the solid tumor microenvironment. CAFs
were once thought to be a relatively uniform population of matrix-producing cells, but single…
were once thought to be a relatively uniform population of matrix-producing cells, but single…
Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human …
The cancer microenvironment allows tumor cells to evade immune surveillance through a
variety of mechanisms. While interferon-γ (IFNγ) is central to effective antitumor immunity, its …
variety of mechanisms. While interferon-γ (IFNγ) is central to effective antitumor immunity, its …
[HTML][HTML] Patient-derived xenograft models for pancreatic adenocarcinoma demonstrate retention of tumor morphology through incorporation of murine stromal …
D Delitto, K Pham, AC Vlada, GA Sarosi… - The American journal of …, 2015 - Elsevier
Direct implantation of viable surgical specimens provides a representative preclinical
platform in pancreatic adenocarcinoma. Patient-derived xenografts consistently demonstrate …
platform in pancreatic adenocarcinoma. Patient-derived xenografts consistently demonstrate …
Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties
Pancreatic ductal adenocarcinoma (PDAC) is almost universally fatal, in large part due to a
protective fibrotic barrier generated by tumor-associated stromal (TAS) cells. This barrier is …
protective fibrotic barrier generated by tumor-associated stromal (TAS) cells. This barrier is …
[HTML][HTML] GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors
Mutant KRas is a significant driver of human oncogenesis and confers resistance to therapy,
underscoring the need to develop approaches that disable mutant KRas-driven tumors. …
underscoring the need to develop approaches that disable mutant KRas-driven tumors. …
Rectal cancer patients younger than 50 years lack a survival benefit from NCCN guideline–directed treatment for stage II and III disease
BACKGROUND The incidence of rectal cancer in patients younger than 50 years is
increasing. To test the hypothesis that the biology in this younger cohort may differ, this study …
increasing. To test the hypothesis that the biology in this younger cohort may differ, this study …
Oncologic and perioperative outcomes following selective application of laparoscopic pancreaticoduodenectomy for periampullary malignancies
D Delitto, CM Luckhurst, BS Black, JL Beck… - Journal of …, 2016 - Elsevier
Background Data are sparse regarding patient selection criteria or evaluating oncologic
outcomes following laparoscopic pancreaticoduodenectomy (LPD). Having prospectively limited …
outcomes following laparoscopic pancreaticoduodenectomy (LPD). Having prospectively limited …