The correct spatial expression of two Drosophila bithorax complex (BX-C) genes, abdominal-A
(abdA) and Abdominal-B (AbdB), is dependent on the 100-kb intergenic infraabdominal (…

Chemotherapy-induced peripheral neuropathy (CIPN) is a serious and often persistent
adverse consequence of certain chemotherapeutic agents. It is a major dose-limiting factor of …

A key question in our understanding of the cis-regulation of gene expression during
embryonic development has been the molecular mechanism that directs enhancers to specific …

The extensive infraabdominal (iab) region contains a number of cis-regulatory elements,
including enhancers, silencers, and insulators responsible for directing the developmental …

It is a long-held belief in evolutionary biology that the rate of molecular evolution for a given
DNA sequence is inversely related to the level of functional constraint. This belief holds true …

Genome sequencing has revealed that in metazoans, only a small percentage of DNA actually
codes for functional proteins. Research efforts have focused on elucidating the purpose …

Introduction: Traumatic brain injury (mTBI) is a leading cause of disability in the US. Angiotensin
1-7, an endogenous peptide, acts at MAS receptors to inhibit inflammatory mediators …

Background While pediatric trauma centers (PTCs) can uniquely care for pediatric patients,
adult trauma centers (ATCs) may be more accessible. Evidence is scarce regarding …

BACKGROUND β-blockers have been shown to improve survival after traumatic brain injury
(TBI); however, the impact of continuous dosage of β-blockers on cognitive function has not …

Atherosclerotic carotid stenosis associated with a mobile carotid plaque (MCP) is a relatively
rare entity, observed in less than 1 in 2,000 carotid ultrasound examinations. As such, the …