[HTML][HTML] Trauma: the role of the innate immune system

F Hietbrink, L Koenderman, GT Rijkers… - World Journal of …, 2006 - Springer
Immune dysfunction can provoke (multiple) organ failure in severely injured patients. This
dysfunction manifests in two forms, which follow a biphasic pattern. During the first phase, in …

Operative treatment versus nonoperative treatment of Achilles tendon ruptures: systematic review and meta-analysis

Y Ochen, RB Beks, M van Heijl, F Hietbrink… - Bmj, 2019 - bmj.com
Objectives To compare re-rupture rate, complication rate, and functional outcome after
operative versus nonoperative treatment of Achilles tendon ruptures; to compare re-rupture rate …

On the origin of low-density neutrophils

…, C van Aalst, S Bongers, F Hietbrink… - Journal of Leukocyte …, 2020 - academic.oup.com
Here we elaborate on the origin of low(er)-density neutrophils (LDNs) to better understand
the variation found in literature. Supplemented with original data, we test the hypothesis that …

Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia

…, VM Kamp, ALT Loi, SW Lam, F Hietbrink… - Journal of leukocyte …, 2010 - academic.oup.com
Systemic inflammation results in release of refractory neutrophils which can cause susceptibility
to infections and activates differentiated neutrophils, which can mediate tissue damage. …

Systemic inflammation increases intestinal permeability during experimental human endotoxemia

F Hietbrink, MGH Besselink, W Renooij, MBM de Smet… - Shock, 2009 - journals.lww.com
Although the gut is often considered the motor of sepsis, the relation between systemic
inflammation and intestinal permeability in humans is not clear. We analyzed intestinal …

[HTML][HTML] Weight-bearing and mobilization in the postoperative care of ankle fractures: a systematic review and meta-analysis of randomized controlled trials and cohort …

…, EJMM Verleisdonk, LPH Leenen, F Hietbrink - PLoS …, 2015 - journals.plos.org
Purpose To determine the effectiveness and safety of interventions used for rehabilitation
after open reduction and internal fixation of ankle fractures. Methods A systematic review and …

[HTML][HTML] Time is of the essence when treating necrotizing soft tissue infections: a systematic review and meta-analysis

…, RM Houwert, LPH Leenen, F Hietbrink - World Journal of …, 2020 - Springer
Background Although the phrase “time is fascia” is well acknowledged in the case of necrotizing
soft tissue infections (NSTIs), solid evidence is lacking. The aim of this study is to review …

[HTML][HTML] Fixation of flail chest or multiple rib fractures: current evidence and how to proceed. A systematic review and meta-analysis

…, KJP Wessem, CF Öner, F Hietbrink… - European Journal of …, 2019 - Springer
Purpose The aim of this systematic review and meta-analysis was to present current evidence
on rib fixation and to compare effect estimates obtained from randomized controlled trials (…

[HTML][HTML] Comparison of analgesic interventions for traumatic rib fractures: a systematic review and meta-analysis

J Peek, DPJ Smeeing, F Hietbrink, RM Houwert… - European Journal of …, 2019 - Springer
Purpose Many studies report on outcomes of analgesic therapy for (suspected) traumatic rib
fractures. However, the literature is inconclusive and diverse regarding the management of …

Surgical versus nonsurgical treatment for midshaft clavicle fractures in patients aged 16 years and older: a systematic review, meta-analysis, and comparison of …

…, DJC Van Der Ven, F Hietbrink… - … American journal of …, 2017 - journals.sagepub.com
Background: There is no consensus on the choice of treatment of midshaft clavicle fractures
(MCFs). Purpose: The aims of this systematic review and meta-analysis were (1) to compare …