: A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive
ligatures around the common sciatic nerve. The postoperative behavior of these rats indicated …

Chronic neuropathic pain, caused by lesions in the peripheral or central nervous system,
comes in many forms. We describe current approaches to the diagnosis and assessment of …

We performed sensory assessments before and during diagnostic tourniquet-cuff and local
anesthetic blocks in 4 patients diagnosed with reflex sympathetic dystrophy (RSD). All …

BACKGROUND Cancers and cancer treatments produce multiple symptoms that collectively
cause a symptom burden for patients. These symptoms include pain, wasting, fatigue, …

The development of new experimental approaches has led to recent ad vances in our
knowledge of spinal and trigeminal nociceptive mechanisms, justifying another review of the …

Paclitaxel (Taxol®) is one of the most effective and frequently used chemotherapeutics for
the treatment of solid tumours. However, paclitaxel produces peripheral neurotoxicity with …

It is self evident that the recent explosive growth in our understanding of the molecular,
cellular and system’s mechanisms responsible for nociception and pain has important …

Paclitaxel chemotherapy frequently induces neuropathic pain during and often persisting
after therapy. The mechanisms responsible for this pain are unknown. Using a rat model of …

Background: Chronic neuropathic pain affects 1%–2% of the adult population and is often
refractory to standard pharmacologic treatment. Patients with chronic pain have reported using …

Paclitaxel, an effective anti-neoplastic agent in the treatment of solid tumors, produces a
dose-limiting painful peripheral neuropathy in a clinically significant number of cancer patients. …