… Gordon H Guyatt, professor1, … Correspondence to: GH Guyatt, CLARITY Research
Group, Department of Clinical Epidemiology and Biostatistics, Room 2C12, 1200 Main Street …

This article introduces the approach of GRADE to rating quality of evidence. GRADE specifies
four categories—high, moderate, low, and very low—that are applied to a body of evidence…

Clinicians and policymakers are recognizing the importance of measuring health-related
quality of life (HRQL) to inform patient management and policy decisions. Self- or interviewer-…

In recent years quality of life instruments have been featured as primary outcomes in many
randomized trials. One of the challenges facing the investigator using such measures is …

CLINICAL SCENARIO You are back where we put you in the previous article 1 on diagnostic
tests in this series on how to use the medical literature: in the library studying an article that …

… Gordon H Guyatt, professor1, … Correspondence to: GH Guyatt, CLARITY Research
Group, Department of Clinical Epidemiology & Biostatistics, Room 2C12, 1200 Main Street …

CLINICAL SCENARIO You are a general internist who is asked to see a 65-year-old man with
controlled hypertension and a 6-month history of atrial fibrillation resistant to cardioversion…

Medical practice is constantly changing. The rate of change is accelerating, and physicians
can be forgiven if they often find it dizzying. How can physicians learn about new information …

The “Grades of Recommendation, Assessment, Development, and Evaluation” (GRADE)
approach provides guidance for rating quality of evidence and grading strength of …

… Author links open overlay panel Gordon H. Guyatt a , Andrew D. Oxman b , Gunn Vist b ,
Regina Kunz c , Jan Brozek a , Pablo Alonso-Coello d , Victor Montori e , Elie A. Akl f , Ben …