Neoplastic transformation has been associated with a variety of structural changes in cell
surface carbohydrates, most notably increased sialylation and β1-6-linked branching of …

T-cell activation requires clustering of a threshold number of T-cell receptors (TCRs) at the
site of antigen presentation, a number that is reduced by CD28 co-receptor recruitment of …

The number of N-glycans (n) is a distinct feature of each glycoprotein sequence and cooperates
with the physical properties of the Golgi N-glycan-branching pathway to regulate surface …

Glycosylation of glycoproteins and glycolipids is one of many molecular changes that
accompany malignant transformation. GlcNAc-branched N-glycans and terminal Lewis antigen …

The Golgi enzyme β1,6 N-acetylglucosaminyltransferase V (Mgat5) is up-regulated in carcinomas
and promotes the substitution of N-glycan with poly N-acetyllactosamine, the preferred …

Golgi β1, 6N-acetylglucosaminyltransferase V (MGAT5) is required in the biosynthesis of β1,
6GlcNAc-branched N-linked glycans attached to cell surface and secreted glycoproteins. …

ContextSevere acute respiratory syndrome (SARS) is a new clinical entity for which no effective
therapeutic strategy has been developed.ObjectiveTo provide preliminary results on the …

Genetic information flows from DNA to macromolecular structures—the dominant force in the
molecular organization of life. However, recent work suggests that metabolite availability to …

N‐ and O‐linked glycan structures of cell surface and secreted glycoproteins serve a variety
of functions related to cell–cell communication in systems affecting development and …

There is a need for anticancer agents with novel mechanisms of action. Recently identified
molecular targets for new anticancer agents include inducers of cell differentiation, cell cycle …