Importance Severely injured patients experiencing hemorrhagic shock often require massive
transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red …

Background: Recognition of trauma-induced coagulopathy by conventional coagulation
testing (CCT) is limited by their slow results, incomplete characterization, and their poor …

Background Aortic occlusion is a potentially valuable tool for early resuscitation in patients
nearing extremis or in arrest from severe hemorrhage. Study Design The American …

Objectives: To determine whether resuscitation of severely injured patients with modified
whole blood (mWB) resulted in fewer overall transfusions compared with component (COMP) …

BACKGROUND There is no consensus as to the optimal treatment paradigm for patients
presenting with hemorrhage from severe pelvic fracture. This study was established to …

Background. Sirolimus, a novel immunosuppressant that inhibits cytokine-driven cell
proliferation and maturation, prolongs allograft survival in animal models. After a phase I trial in …

Objective. Earlier use of plasma and red blood cells (RBCs) has been associated with
improved survival in trauma patients with substantial hemorrhage. We hypothesized that …

Background Tourniquet use has been proven to reduce mortality on the battlefield. Although
empirically transitioned to the civilian environment, data substantiating survival benefit …

Background Forty percent of in-hospital deaths among injured patients involve massive
truncal haemorrhage. These deaths may be prevented with rapid haemorrhage control and …

BACKGROUND Injury leads to dramatic disturbances in coagulation with increased risk of
bleeding followed by a hypercoagulable state. A comprehensive assessment of these …