A cornerstone of modern biomedical research is the use of mouse models to explore basic
pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-…

Human survival from injury requires an appropriate inflammatory and immune response. We
describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well …

Limited data are available on the relation between physical fitness and mortality from
cardiovascular disease. We examined this question in a study of 4276 men, 30 to 69 years of age, …

Objective To assess the clinical utility of abdominal perfusion pressure (mean arterial
pressure minus intra-abdominal pressure) as both a resuscitative endpoint and predictor of …

Background: Massive transfusion protocols (MTPs) have become standard of care in the
management of bleeding injured patients, yet strategies to guide them vary widely. We …

Purpose: In a series of trials, doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD)
and mechlorethamine, vincristine, procarbazine, prednisone, doxorubicin, bleomycin, and …

Transfusion-related acute lung injury (TRALI) is a serious complication of hemotherapy. During
blood storage, lipids are generated and released into the plasma. In this study, the role of …

Purpose Concerns regarding neurocognitive toxicity of whole-brain radiotherapy (WBRT)
have motivated development of alternative, dose-intensive chemotherapeutic strategies as …

Background: Recent military experience suggests that immediate 1: 1 fresh frozen plasma (FFP);
red blood cells (RBC) for casualties requiring> 10 units packed red blood cells (RBC) …

Background: The current management of pelvic fracture patients who are hemodynamically
unstable in the United States consists of aggressive resuscitation, mechanical stabilization, …