A cornerstone of modern biomedical research is the use of mouse models to explore basic
pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-…

Human survival from injury requires an appropriate inflammatory and immune response. We
describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well …

Objective: The detrimental effects of coagulopathy, hypothermia, and acidosis are well
described as markers for mortality after traumatic hemorrhage. Recent military experience …

Background: Blood transfusion is known to be an independent risk factor for mortality,
multiple organ failure (MOF), acute respiratory distress syndrome (ARDS), and nosocomial …

Objective: The mixed venous-arterial (va) pCO 2 difference has been shown to be inversely
correlated with the cardiac index (CI). A central venous pCO 2 , which is easier to obtain, …

Purpose To provide evidence-based recommendations on the use of inferior vena cava (IVC)
filters in the treatment of patients with or at substantial risk of venous thromboembolic …

Background: The incidence of venous thromboembolism (VTE) without prophylaxis is as high
as 80% after major trauma. Initiation of prophylaxis is often delayed because of concerns …

BACKGROUND: Massive transfusion (MT) protocols have emphasized the importance of
ratio-based transfusion of plasma and platelets relative to packed red blood cells (PRBCs); …

Objectives: To describe the incidence of postinjury multiple organ failure and its relationship
to nosocomial infection and mortality in trauma centers using evidence-based standard …

Background: Prehospital intubation has been challenged on the grounds that it predisposes
to hyperventilation, which is detrimental after traumatic brain injury (TBI), and impairs …