The administration of therapeutic doses of recombinant cytokines to patients with malignant
disease can be complicated by systemic toxicities, which in their most severe form may …

Purpose: On the basis of preclinical studies, we hypothesized that interleukin (IL)12 would
potentiate the antitumor actions of an antihuman epidermal growth factor receptor-2 (HER2) …

Background. Despite advances in antiviral chemotherapy, herpes simplex virus type 1 (HSV-1),
continues to complicate the clinical course of many allograft recipients. We have …

Abdominal vascular trauma, primarily due to penetrating mechanisms, is uncommon.
However, when it does occur, it can be quite lethal, with mortality ranging from 20% to 60%. …

Posttransplantation lymphoproliferative disorder (PTLD) is a devastating post-transplantation
complication often associated with Epstein-Barr virus (EBV). Although the type and length …

The anti-tumor activity of recombinant mAb’s directed against tumor cell growth receptors
has generally been considered to result from direct antiproliferative effects, the induction of …

The Her2 / neu (c‐erbB‐2) oncogene encodes a 185‐kDa protein tyrosine kinase which is
overexpressed in 20 % of breast adenocarcinomas and is recognized by a humanized anti‐…

The mechanism of cytokine-induced shock remains poorly understood. The combination of
IL-2 and IL-12 has synergistic antitumor activity in vivo, yet has been associated with …

Background. Cooperative interactions between natural killer (NK) cells and macrophages
occur normally during the course of the early immune response to bacterial, protozoal, and …

Nitric oxide production by mouse macrophages treated with group B streptococci and gamma
interferon was inhibited by cytochalasin B or by antibody neutralization of macrophage-…