Transfusion of plasma, platelets, and red blood cells in a 1: 1: 1 vs a 1: 1: 2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial

…, CE Wade, JM Podbielski, DJ del Junco, KJ Brasel… - Jama, 2015 - jamanetwork.com
Importance Severely injured patients experiencing hemorrhagic shock often require massive
transfusion. Earlier transfusion with higher blood product ratios (plasma, platelets, and red …

The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks

…, MA Schreiber, LH Alarcon, Y Bai, KJ Brasel… - JAMA …, 2013 - jamanetwork.com
Objective To relate in-hospital mortality to early transfusion of plasma and/or platelets and to
time-varying plasma:red blood cell (RBC) and platelet:RBC ratios. Design Prospective …

Advanced trauma life support, the evidence for change

…, J Ali, JA Antoine, B Bouillon, K Brasel… - Journal of Trauma …, 2008 - journals.lww.com
The American College of Surgeons Committee on Trauma’s Advanced Trauma Life Support
Course is currently taught in 50 countries. The 8th edition has been revised following broad …

Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial

EM Bulger, S May, KJ Brasel, M Schreiber, JD Kerby… - Jama, 2010 - jamanetwork.com
Context Hypertonic fluids restore cerebral perfusion with reduced cerebral edema and
modulate inflammatory response to reduce subsequent neuronal injury and thus have potential …

Out-of-hospital hypertonic resuscitation after traumatic hypovolemic shock: a randomized, placebo controlled trial

…, S Emerson, IG Stiell, MA Schreiber, KJ Brasel… - Annals of …, 2011 - journals.lww.com
Objective: To determine whether out-of-hospital administration of hypertonic fluids would
improve survival after severe injury with hemorrhagic shock. Background: Hypertonic fluids …

Models for structuring a clinical initiative to enhance palliative care in the intensive care unit: a report from the IPAL-ICU Project (Improving Palliative Care in the ICU)

JE Nelson, R Bassett, RD Boss, KJ Brasel… - Critical care …, 2010 - journals.lww.com
Objective: To describe models used in successful clinical initiatives to improve the quality of
palliative care in critical care settings. Data Sources: We searched the MEDLINE database …

Perceived gender-based barriers to careers in academic surgery

…, WB Elder, LA Neumayer, KJ Brasel… - The American Journal of …, 2013 - Elsevier
Background Women represent roughly 50% of US medical students and one third of US
surgery residents. Within academic surgery departments, however, women are …

Clinical and mechanistic drivers of acute traumatic coagulopathy

…, JG Myers, MH Rahbar, KJ Brasel… - Journal of Trauma …, 2013 - journals.lww.com
BACKGROUND Acute traumatic coagulopathy (ATC) occurs after severe injury and shock
and is associated with increased bleeding, morbidity, and mortality. The effects of ATC and …

Surgical “buy-in”: the contractual relationship between surgeons and patients that influences decisions regarding life-supporting therapy

ML Schwarze, CT Bradley, KJ Brasel - Critical care medicine, 2010 - journals.lww.com
Objective: There is a general consensus by intensivists and nonsurgical providers that
surgeons hesitate to withdraw life-sustaining therapy on their operative patients despite a …

Rib fractures: relationship with pneumonia and mortality

KJ Brasel, CE Guse, P Layde, JA Weigelt - Critical care medicine, 2006 - journals.lww.com
Objective: In single-institution studies, age is a risk factor for mortality after rib fracture.
Sample size has limited the assessment of other risk factors. We used a national database to …