[HTML][HTML] Global changes in mortality rates in polytrauma patients admitted to the ICU—a systematic review

…, LPH Leenen, KJP van Wessem - World Journal of …, 2020 - Springer
Background Many factors of trauma care have changed in the last decades. This review
investigated the effect of these changes on global all-cause and cause-specific mortality in …

[HTML][HTML] Neutrophil heterogeneity and its role in infectious complications after severe trauma

L Hesselink, R Spijkerman, KJP van Wessem… - World Journal of …, 2019 - Springer
Background Trauma leads to a complex inflammatory cascade that induces both immune
activation and a refractory immune state in parallel. Although both components are deemed …

[HTML][HTML] Current treatment and outcomes of traumatic sternal fractures—a systematic review

…, FC Öner, LPH Leenen, KJP van Wessem - International …, 2019 - Springer
Purpose Traumatic sternal fractures are rare injuries. The most common mechanism of injury
is direct blunt trauma to the anterior chest wall. Most (> 95%) sternal fractures are treated …

Epidemiology of traumatic deaths: comprehensive population-based assessment

JA Evans, KJP van Wessem, D McDougall… - World journal of …, 2010 - Springer
Background The epidemiology of traumatic deaths was periodically described during the
development of the American trauma system between 1977 and 1995. Recognizing the impact …

[HTML][HTML] Demographic patterns and outcomes of patients in level I trauma centers in three international trauma systems

AC Gunning, KWW Lansink, KJP van Wessem… - World journal of …, 2015 - Springer
Introduction Trauma systems were developed to improve the care for the injured. The
designation and elements comprising these systems vary across countries. In this study, we have …

[HTML][HTML] Incidence, causes and consequences of moderate and severe traumatic brain injury as determined by Abbreviated Injury Score in the Netherlands

…, LPH Leenen, RM Houwert, KJP van Wessem - Scientific reports, 2021 - nature.com
Traumatic brain injury (TBI) is a leading cause of death and disability. Epidemiology seems
to be changing. TBIs are increasingly caused by falls amongst elderly, whilst we see less …

Reduction in mortality rates of postinjury multiple organ dysfunction syndrome: a shifting paradigm? A prospective population-based cohort study

KJP Van Wessem, LPH Leenen - Shock, 2018 - journals.lww.com
Results: One hundred fifty-seven patients were included. Median age was 45 (26–61) years,
118 males (75%), ISS was 29 (22–37), 151 (96%) patients had blunt injuries. Thirty-one …

[HTML][HTML] Persistent inflammation, immunosuppression and catabolism syndrome (PICS) after polytrauma: a rare syndrome with major consequences

…, MCH de Groot, KJP van Wessem… - Journal of Clinical …, 2020 - mdpi.com
Nowadays, more trauma patients develop chronic critical illness (CCI), a state characterized
by prolonged intensive care. Some of these CCI patients have disproportional difficulties to …

[HTML][HTML] Point-of-care analysis of neutrophil phenotypes: a first step toward immuno-based precision medicine in the trauma ICU

…, L Hesselink, S Bongers, KJP van Wessem… - Critical care …, 2020 - journals.lww.com
Objectives: The amount of tissue damage and the amplitude of the immune response after
trauma are related to the development of infectious complications later on. Changes in the …

Incidence of acute respiratory distress syndrome and associated mortality in a polytrauma population

KJP van Wessem, LPH Leenen - Trauma surgery & acute care open, 2018 - tsaco.bmj.com
Background The incidence of acute respiratory distress syndrome (ARDS) has decreased in
the last decade by improvement in trauma and critical care. However, it still remains a major …