… Contributors: Kenneth Rockwood designed the study, wrote the first and final drafts of the …
and Kenneth Rockwood previously devised and tested the Frailty Index.) Kenneth Rockwood, …

Frailty is the most problematic expression of population ageing. It is a state of vulnerability to
poor resolution of homoeostasis after a stressor event and is a consequence of cumulative …

This review article summarizes how frailty can be considered in relation to deficit
accumulation. Recalling that frailty is an age-associated, nonspecific vulnerability, we consider …

Executive summary Acting now on dementia prevention, intervention, and care will vastly
improve living and dying for individuals with dementia and their families, and in doing so …

The number of older people, including those living with dementia, is rising, as younger age
mortality declines. However, the age-specific incidence of dementia has fallen in many …

Cerebrovascular disease is the second most common cause of acquired cognitive impairment
and dementia and contributes to cognitive decline in the neurodegenerative dementias. …

Between 1977 and 1984, 48 girls but only 26 boys were born to parents exposed to 2, 3, 7,
8 tetrachlorodibenzo-p-dioxin (TCDD, or dioxin) in Seveso, Italy. 1 The 1976 industrial …

Context Dementia is common, costly, and highly age related. Little attention has been paid
to the identification of modifiable lifestyle habits for its prevention. Objective To explore the …

Background Frailty can be measured in relation to the accumulation of deficits using a frailty
index. A frailty index can be developed from most ageing databases. Our objective is to …

This paper develops a method for appraising health status in elderly people. A frailty index
was defined as the proportion of accumulated deficits (symptoms, signs, functional …