User profiles for Priya S Prakash

Priya Prakash

University of Chicago
Verified email at surgery.bsd.uchicago.edu
Cited by 1985

Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis

…, J McDonough, M Morre, PS Prakash… - The Journal of …, 2012 - academic.oup.com
Background. Secondary hospital-acquired fungal infections are common in critically-ill patients
and mortality remains high despite antimicrobial therapy. Interleukin-7 (IL-7) is a potent …

Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through γδ T-cell IL-17 production in a murine model of sepsis

KR Kasten, PS Prakash, J Unsinger… - Infection and …, 2010 - Am Soc Microbiol
The sepsis syndrome represents an improper immune response to infection and is associated
with unacceptably high rates of mortality and morbidity. The interactions between T cells …

Microparticles from stored red blood cells activate neutrophils and cause lung injury after hemorrhage and resuscitation

RM Belizaire, PS Prakash, JR Richter… - Journal of the …, 2012 - journals.lww.com
Background Transfusion of stored blood is associated with increased complications.
Microparticles (MPs) are small vesicles released from RBCs that can induce cellular dysfunction, …

Human microparticles generated during sepsis in patients with critical illness are neutrophil-derived and modulate the immune response

PS Prakash, CC Caldwell, AB Lentsch… - Journal of Trauma …, 2012 - journals.lww.com
BACKGROUND Microparticles (MPs) are 0.3 μm to 1.0 μm vesicles generated after cell
activation or apoptosis that may play a role in the pathophysiology of sepsis. We sought to …

Predictors of retained hemothorax in trauma: Results of an Eastern Association for the Surgery of Trauma multi-institutional trial

PS Prakash, SA Moore, JB Rezende-Neto… - Journal of Trauma …, 2020 - journals.lww.com
BACKGROUND The natural history of traumatic hemothorax (HTX) remains unclear. We
aimed to describe outcomes of HTX following tube thoracostomy drainage and to delineate …

Similar hematological and biochemical parameters among periodontitis and control group subjects

S Prakash, K Dhingra, S Priya - European journal of dentistry, 2012 - thieme-connect.com
Objectives: There are conflicting reports in the past literature documenting the tendency of
anemia in patients with periodontitis. Hence, this study was undertaken to assess whether …

[HTML][HTML] Neutrophil derived microparticles increase mortality and the counter-inflammatory response in a murine model of sepsis

BL Johnson III, EF Midura, PS Prakash, TC Rice… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Although advances in medical care have significantly improved sepsis survival, sepsis
remains the leading cause of death in the ICU. This is likely due to a lack of complete …

Mechanisms underlying mouse TNF-α stimulated neutrophil derived microparticle generation

BL Johnson III, HS Goetzman, PS Prakash… - Biochemical and …, 2013 - Elsevier
Despite advances in understanding and treatment of sepsis, it remains a disease with high
mortality. Neutrophil Derived Microparticles (NDMPs) are present during sepsis and can …

Predictors of initial management failure in traumatic hemothorax: A prospective multicenter cohort analysis

…, MJ Seamon, JW Cannon, I Afif, PS Prakash, S Trpcic… - Surgery, 2023 - Elsevier
Background Traumatic hemothorax is common, and management failure leads to worse
outcomes. We sought to determine predictive factors and understand the role of trauma center …

Impact of caspase-8 and PKA in regulating neutrophil-derived microparticle generation

EF Midura, PS Prakash, BL Johnson III, TC Rice… - Biochemical and …, 2016 - Elsevier
The morbidity and mortality from sepsis continues to remain high despite extensive research
into understanding this complex immunologic process. Further, while source control and …