Background: Effective antiviral drugs for COVID-19 are still lacking. This study aims to
evaluate the clinical outcomes and plasma concentrations of baloxavir acid and favipiravir in …

There is increasing evidence that inducing neuronal mitophagy can be used as a
therapeutic intervention for Alzheimer’s disease. Here, we screen a library of 2024 FDA-approved …

Although the strategy for administering antibodies orally for inflammatory bowel disease (IBD)
treatment has been proposed, the rational design for efficient delivery system is still a …

Background— Stromal cell–derived factor-1α (SDF-1α) is implicated as a chemokine for
endothelial progenitor cells (EPCs). We therefore hypothesized that SDF-1α gene transfer …

Activated monocytes are present in the arterial walls of hypertensive patients and animals.
Monocyte chemoattractant protein-1 (MCP-1), which controls monocyte function through its …

Neointimal hyperplasia is a major cause of restenosis after coronary intervention. Because
vascular injury is now recognized to involve an inflammatory response, monocyte …

Background— NADPH oxidase 4 (Nox4) has been implicated in cardiac remodeling, but its
precise role in cardiac injury remains controversial. Furthermore, little is known about the …

Angiotensin II (Ang II) upregulates vascular endothelial growth factor (VEGF) and activates
vascular inflammation. However, the decisive role of VEGF in Ang II–induced vascular …

Chaperone-mediated autophagy (CMA) is a lysosome-dependent selective degradation
pathway implicated in the pathogenesis of cancer and neurodegenerative diseases. However, …

Rationale: The enhanced formation of intracellular reactive oxygen species (ROS) induced
by oxidized low-density lipoprotein (OxLDL) promotes macrophage death, a process likely to …