User profiles for Tyler Loftus

Tyler J. Loftus

University of Florida
Verified email at surgery.ufl.edu
Cited by 3171

Artificial intelligence and surgical decision-making

TJ Loftus, PJ Tighe, AC Filiberto, PA Efron… - JAMA …, 2020 - jamanetwork.com
Importance Surgeons make complex, high-stakes decisions under time constraints and
uncertainty, with significant effect on patient outcomes. This review describes the weaknesses of …

[HTML][HTML] DeepSOFA: a continuous acuity score for critically ill patients using clinically interpretable deep learning

B Shickel, TJ Loftus, L Adhikari, T Ozrazgat-Baslanti… - Scientific reports, 2019 - nature.com
Traditional methods for assessing illness severity and predicting in-hospital mortality among
critically ill patients require time-consuming, error-prone calculations using static variable …

[HTML][HTML] Innate immunity in the persistent inflammation, immunosuppression, and catabolism syndrome and its implications for therapy

H Horiguchi, TJ Loftus, RB Hawkins… - Frontiers in …, 2018 - frontiersin.org
Clinical and technological advances promoting early hemorrhage control and physiologic
resuscitation as well as early diagnosis and optimal treatment of sepsis have significantly …

[HTML][HTML] Microbial recognition and danger signals in sepsis and trauma

…, DC Holden, JC Mira, JA Stortz, TJ Loftus… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Early host recognition of microbial invasion or damaged host tissues provides an effective
warning system by which protective immune and inflammatory processes are initiated. Host …

Evidence for persistent immune suppression in patients who develop chronic critical illness after sepsis

…, R Ungaro, ML Dirain, DC Nacionales, TJ Loftus… - Shock, 2018 - journals.lww.com
Background: Many sepsis survivors develop chronic critical illness (CCI) and are assumed
to be immunosuppressed, but there is limited clinical evidence to support this. We sought to …

Serum levels of prealbumin and albumin for preoperative risk stratification

TJ Loftus, MP Brown, JH Slish… - Nutrition in Clinical …, 2019 - Wiley Online Library
Preoperative risk stratification has long been developed as a strategy to predict postoperative
outcomes and potentially alter or optimize comorbidities and modifiable risk. Malnutrition is …

Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients

JA Stortz, JC Mira, SL Raymond, TJ Loftus… - Journal of Trauma …, 2018 - journals.lww.com
BACKGROUND A growing number of patients survive sepsis but remain chronically critically
ill. We sought to define clinical outcomes and incidence of chronic critical illness (CCI) after …

[HTML][HTML] Ideal algorithms in healthcare: explainable, dynamic, precise, autonomous, fair, and reproducible

TJ Loftus, PJ Tighe, T Ozrazgat-Baslanti… - PLOS digital …, 2022 - journals.plos.org
Established guidelines describe minimum requirements for reporting algorithms in
healthcare; it is equally important to objectify the characteristics of ideal algorithms that confer …

Clinical impact of a dedicated trauma hybrid operating room

TJ Loftus, CA Croft, MD Rosenthal, AM Mohr… - Journal of the American …, 2021 - Elsevier
Background Early hemorrhage control is essential to optimal trauma care. Hybrid operating
rooms offer early, concomitant performance of advanced angiographic and operative …

The epidemiology of chronic critical illness after severe traumatic injury at two level–one trauma centers

…, Z Wang, GL Ghita, TJ Loftus… - Critical care …, 2017 - journals.lww.com
Loftus’s institution received funding from the NIH. Dr. Raymond’s institution received
support from the NIGMS. … Verdugo, and Tyler L. Murphy to the execution of this study. …