In recent years, RNA-sequencing (RNA-seq) has emerged as a powerful technology for
transcriptome profiling. For a given gene, the number of mapped reads is not only dependent on …

Transcription factors control cell-specific gene expression programs through interactions
with diverse coactivators and the transcription apparatus. Gene activation may involve DNA …

We describe a method, Hi–C, to comprehensively detect chromatin interactions in the
mammalian nucleus. This method is based on Chromosome Conformation Capture, in which …

Mitotic chromosomes are among the most recognizable structures in the cell, yet for over a
century their internal organization remains largely unsolved. We applied chromosome …

Background The processing of dietary lipids in the intestinal lumen involves metabolic
processes of the host and also of the microbial organisms that reside in the gut. Whereas, in the …

The rapeseed (Brassica napus L.) are the important oil bearing material worldwide, which
contain wide variety of bioactive components with polyphenolic compounds considered the …

Background Tracking longitudinal measurements of growth and decline in lung function in
patients with persistent childhood asthma may reveal links between asthma and subsequent …

Mammalian interphase chromosomes interact with the nuclear lamina (NL) through hundreds
of large lamina-associated domains (LADs). We report a method to map NL contacts …

Objective: To evaluate the relationship between serum cholesterol level and all-cause,
coronary heart disease (CHD), and non-CHD mortality as a function of age. Methods: The data …

X-chromosome inactivation (XCI) involves major reorganization of the X chromosome as it
becomes silent and heterochromatic. During female mammalian development, XCI is …