Figure 2 Alteration of coagulation parameters correlates with the severity of injury score in trauma patients (n=100). The blood samples were collected from healthy volunteers (normal, n=20) or trauma patients at admission (admi.), 45, 90, 135 minutes, and 18 hours postadmission, and coagulation parameters such as PT (A), PTT (B), D-dimer (C), factor I (D), factor II (E), and factor XII (F) in the plasma fractions were measured. Statistical analyses were performed by two-way ANOVA, *, †, and ‡p<0.05 vs healthy volunteers, ISS<10 patients (n=63), and ISS=10–20 patients (n=19), respectively. ANOVA, analysis of variance; ISS, injury severity score; PT, partial thromboplastin; PTT, partial thromboplastin time.