Skip to main content

Main menu

  • Latest content
    • Latest content
  • Archive
  • About the journal
    • About the journal
    • Editorial board
    • Information for authors
    • FAQs
    • Thank you to our reviewers
    • The American Association for the Surgery of Trauma
  • Submit a paper
    • Online submission site
    • Information for authors
  • Email alerts
    • Email alerts
  • Help
    • Contact us
    • Feedback form
    • Reprints
    • Permissions
    • Advertising
  • BMJ Journals

User menu

  • Login

Search

  • Advanced search
  • BMJ Journals
  • Login
  • Facebook
  • Twitter
TSACO

Advanced Search

  • Latest content
    • Latest content
  • Archive
  • About the journal
    • About the journal
    • Editorial board
    • Information for authors
    • FAQs
    • Thank you to our reviewers
    • The American Association for the Surgery of Trauma
  • Submit a paper
    • Online submission site
    • Information for authors
  • Email alerts
    • Email alerts
  • Help
    • Contact us
    • Feedback form
    • Reprints
    • Permissions
    • Advertising
Open Access

Effects of a trauma center on early mortality after trauma in a regional city in Japan: a population-based study

Yuji Takahashi, Shuntaro Sato, Kazunori Yamashita, Naoya Matsumoto, Yoshihiro Nozaki, Tomohito Hirao, Goro Tajima, Takamitsu Inokuma, Shuhei Yamano, Kensuke Takahashi, Takashi Miyamoto, Kenichiro Inoue, Makoto Osaki, Osamu Tasaki
DOI: 10.1136/tsaco-2018-000291 Published 2 June 2019
Yuji Takahashi
1Department of Emergency Medicine, Unit of Clinical Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
2Inoue Hospital, Nagasaki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shuntaro Sato
3Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kazunori Yamashita
4Acute & Critical Care Center, Nagasaki University Hospital, Nagasaki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Naoya Matsumoto
4Acute & Critical Care Center, Nagasaki University Hospital, Nagasaki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yoshihiro Nozaki
4Acute & Critical Care Center, Nagasaki University Hospital, Nagasaki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tomohito Hirao
4Acute & Critical Care Center, Nagasaki University Hospital, Nagasaki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Goro Tajima
4Acute & Critical Care Center, Nagasaki University Hospital, Nagasaki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Takamitsu Inokuma
4Acute & Critical Care Center, Nagasaki University Hospital, Nagasaki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shuhei Yamano
4Acute & Critical Care Center, Nagasaki University Hospital, Nagasaki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kensuke Takahashi
5Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
6Department of Infectious Diseases, Nagasaki University Hospital, Nagasaki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Takashi Miyamoto
4Acute & Critical Care Center, Nagasaki University Hospital, Nagasaki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kenichiro Inoue
2Inoue Hospital, Nagasaki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Makoto Osaki
7Department of Orthopaedic Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Osamu Tasaki
1Department of Emergency Medicine, Unit of Clinical Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
4Acute & Critical Care Center, Nagasaki University Hospital, Nagasaki, Japan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • PDF
Loading

Abstract

Background Although the effects of the trauma center(TC) were researched in several studies, there have been few studies on changes in the regional mortality due to the implementation of a TC. An emergency medical center (EMC) and TC were implemented at Nagasaki University Hospital (NUH) for the first time in the Nagasaki medical region of Japan in April 2010 and October 2011, respectively, and they have cooperated with each other in treating trauma patients. The purpose of this study was to investigate the effects on the early mortality at population level of a TC working in cooperation with an EMC.

Methods This is a retrospective study using standardized regional data (ambulance service record) in Nagasaki medical region from April 2007 through March 2017. We included 19,045 trauma patients directly transported from the scene. The outcome measures were prognosis for one week. To examine the association between the implementation of the EMC and TC and mortality at a region, we fit adjusted logistic regression models.

Results The number of patients of each fiscal year increased from 1492 in 2007 to 2101 in 2016. The number of all patients transported to NUH decreased until 2009 to 70, but increased after implementation of the EMC and TC. Overall mortality of all patients in the region improved from 2.3% in 2007 to 1.0% in 2016.In multivariate logistic regression model, odds ratio of death was significantly smaller at 2013 and thereafter if the data from 2007 to 2011 was taken as reference.

Conclusions Implementation of the EMC and TC was associated with early mortality in trauma patients directly transported from the scene by ambulance. Our analysis suggested that the implementation of EMC and TC contributed to the improvement of the early mortality at a regional city with 500000 populations.

Level of evidence Level III.

Introduction

Trauma is a major cause of mortality in Japan, especially in young people.1 Some research reports investigated the reduction of mortality at an institution after a quality improvement programme was instituted at a single trauma center (TC).2–4 Several studies have also shown a significant decrease in mortality among severely injured patients treated at hospital with a TC compared with those treated at non-TC hospitals in adults5 and in children.6 7 However, few studies have investigated the changes in regional mortality following the implementation of a TC. An emergency medical center (EMC) and TC were implemented at Nagasaki University Hospital (NUH) for the first time in the Nagasaki medical region of Japan in April 2010 and October 2011, respectively, and they have cooperated with each other in treating trauma patients. We hypothesized that implementation of EMC and TC capable of treating severe trauma patients led to reduction in mortality of 500 000 population medical area. Therefore, the purpose of this study was to investigate the effects on the early mortality at population level of a TC working in cooperation with an EMC.

Materials and methods

Study design and data

We conducted a retrospective study using standardized regional data (ambulance service records) collected in the Nagasaki medical region. Nagasaki ambulance service has three fire departments and each department has satellite service (total 19 services). In Japan, it is determined by law that all ambulance service should record prehospital transports data. The data were collected for all patients taken to hospitals in an ambulance and included prehospital information and both the definitive diagnosis and outcome at 1 week after injury (returned home, hospitalization, discharged, transferred to a higher-level medical institution, transferred to other institution, death in the emergency room (ER), death after hospitalization). All hospitals in the Nagasaki medical region were encouraged to submit their records (participation rate 100%, collection rate 91.6%). Mortality as the primary outcome of this study was a composite of death in the ER and that after hospitalization.

Study setting

The Nagasaki medical region, with an area of about 456 km2 and population of about 500 000 people, is located in the southern part of Nagasaki prefecture in Japan. There were 26 acute care hospitals in the region in April 2010, at which time NUH implemented an EMC as a tertiary emergency medical institution certified by Nagasaki prefecture. NUH had 862 beds. The EMC had eight beds in its intensive care unit and 19 beds in its high-care unit and was served by nine members including a surgeon, neurosurgeon, orthopedist, anesthesiologist, cardiologist, neurologist, neurosurgeon and emergency physician. They had no duty other than taking care of patients in EMC. There were no regulations at the time on the establishment of a TC in Japan. Therefore, we started with three orthopedists and one plastic surgeon, and they cooperated with the EMC staff and could also consult with the doctors of other departments in the hospital, especially when they cared for severely injured patients.

Ambulance services triaged trauma patients by physiological evaluation (consciousness: Japan Coma Scale ≥100; breathing: respiratory rate <10 or ≥30/min, etc; circulation: systolic blood pressure <90 or ≥200 mm Hg, etc), anatomical evaluation (suspected of flail chest, pelvic fracture, etc), and assessment of injury situation (fellow passenger’s death, rollover accident, etc). Although the triage criteria had existed since the time before implementation of EMC, NUH were not fully ready to accept severe trauma patients. NUH announced publicly before opening EMC that it would aggressively accept critically ill patients hard to treat in the other hospitals and also announced again before opening TC.

Study population

Analyses were performed during April 2007–March 2017. Since EMC was implemented in April 2010 and TC was in October 2011, we defined fiscal 2007 to 2011 as pre-EMC&TC period, and fiscal 2012–2016 as post-EMC&TC period.

There were 13 main diagnostic codes used by the treating physicians. Coding of injuries due to external causes was divided into traumatic intracranial hemorrhage, cardiovascular and lung injury, abdominal organ injury, pelvic fracture, proximal femur fracture, other fractures, severe multiple trauma, spinal cord injury, asphyxia, burn, drowning, poisoning, and minor injuries. Trauma patients directly transported from the scene in the Nagasaki medical region were included in the present study.

First, we excluded cases with no definitive diagnosis, no description of outcome, and unknown accident type in the ambulance service record (figure 1). Next, cases with medical illness were excluded, and the codes such as asphyxia, burn, drowning, poisoning, and minor injuries including sprains and strains were excluded from cases with an external cause of injury. Thus, trauma patients were defined as those having the following codes: traumatic intracranial hemorrhage, spinal cord injury, cardiovascular and lung injury, abdominal organ injury, pelvic fracture, proximal femur fracture, severe multiple trauma, and other fractures. Finally, we excluded patients transferred from another hospital and those with unknown transport type. Codes selection was performed at the discretion of the treating physicians. Severe multiple trauma was defined as severe injuries involving multiple body regions.

Figure 1
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 1

Derivation of the study sample from the standardized regional data in the Nagasaki medical region.

Because of the anonymous nature of the data, the requirement for informed consent was waived.

Statistical analysis

Our analysis investigated the association between mortality and implementation of the EMC and TC. First, we evaluated risk via adjusted OR, 95% CIs, and p values for mortality with multivariable logistic regression models adjusted for years since implementation of the EMC and TC, age, sex, site (NUH vs non-NUH (ie, patients not transported to NUH)), trauma code, and time from emergency call to hospital arrival. We also performed subgroup analyses across three age strata using the above multivariable logistic regression model except for age because ageing of the population was observed throughout the study. In addition, we showed transitions of the number of trauma patients, each injury, age, age subgroup, sex, and time from emergency call every year. Whether these transitions to monotonically increase or decrease were analyzed by a linear regression model. Yearly rates of patients transported to NUH were analyzed by a Poisson regression model. A p value of <0.05 was considered to indicate statistical significance. All analyses were performed using R V.3.5.2 (R Foundation).

Results

From April 2007 to March 2017, 202 554 patients were transported in the region, and the rate of record collection was 91.6% (n=185 559). In total, 19 045 trauma patients directly transported from the scene were eligible for our analyses (figure 1). The number of patients significantly increased each fiscal year from 1492 in 2007 to 2101 in 2016 (online supplemental table). The mean of age significantly increased from 66.7 in 2007 to 72.5 in 2016 (online supplemental table). Both the mean time from emergency call to the scene and that to hospital arrival were significantly increased by 2.4 min and 8.2 min (online supplemental table), respectively, suggesting that the ambulance service was getting worse mainly due to an increase in the number of patient transports. Among the injuries, other fractures occurred most frequently followed by proximal femur fracture, traumatic intracranial hemorrhage, and pelvic fracture, and these four types of injuries significantly increased during the study period (online supplemental table). The number of all patients transported to NUH decreased until 2009 to 70 but tended to increase after implementation of the EMC and TC although rate of transport did not significantly change (online supplemental table). The percentage of patients transported to NUH with cardiovascular and lung injury significantly increased during the study period (online supplemental table). The rate of transportation to NUH for other fractures and proximal femur fracture remained low throughout the study period (online supplemental table). Mortality in non-NUH hospitals increased to 1.9% until 2009 but decreased after 2010 to 0.6% (table 1, figure 2). However, mortality in NUH was high although it tended to decline during the study period. As a result, overall mortality of all patients in the region improved from 2.3% in 2007 to 1.0% in 2016.

Supplementary data

[tsaco-2018-000291supp001.docx]
View this table:
  • View inline
  • View popup
Table 1

Outcome 1 week after injury

Figure 2
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 2

Serial changes in morality. Black line represents overall mortality. *p<0.05 versus mortality of 2007–2011 by multivariable logistic regression model. NUH, transported to Nagasaki University Hospital; non-NUH, transported to non-Nagasaki University Hospital.

The results of the multivariable logistic regression are shown in table 2.

View this table:
  • View inline
  • View popup
Table 2

Results of logistic regression model

When the data from 2007 to 2011 (pre-EMC&TC period) was used as a reference, ORs of death were significantly smaller in 2013 and thereafter. ORs of traumatic intracranial hemorrhage, cardiovascular and lung injury, abdominal organ injury, pelvic fracture, severe multiple trauma, and spinal cord injury were significantly higher compared with that for proximal femur fracture. OR of transported site (NUH) was significantly high when non-NUH was used as a reference suggesting that more severe patients were transported to NUH. Neither age nor transportation time was significantly associated with mortality. Because ageing of the population was observed throughout the study, we also performed a subgroup analysis of three age groups: pediatrics (0–14 years), adults (15–64 years), and elderly (>64 years). Although only one patient died during the study period, pediatric mortality in the region showed no change. In the adult group, OR of death in 2013 was significantly reduced compared with that from pre-EMC&TC period, and ORs of death in 2015 and 2016 were significantly reduced in the elderly group (tables 1 and 2). These findings indicate that the reduction of mortality in all patients was due not only to the reduction of mortality in the elderly group but also to that in the adult group. Figure 3 shows the ORs of death in each year as a reference with pre-EMC&TC period. During post-EMC&TC period, the ORs were less than 1.0, so the risk of death was low. A significant difference was recognized from fiscal year 2013.

Figure 3
  • Download figure
  • Open in new tab
  • Download powerpoint
Figure 3

ORs of death in each year as a reference with pre-EMC&TC period. A significant difference is recognized from fiscal year 2013. *p<0.05 versus mortality of 2007–2011 by multivariable logistic regression model.

Discussion

The present study investigated the effects of the implementation of EMC and TC on mortality at a population level. Because the period between implementation of the EMC and TC was short and the two centers cooperated with each other, the single effect of the TC could not be evaluated.

The important feature of this study was that our target was all patients directly transported by ambulance to all hospitals in the region. Previous studies showed that the effects of constructing a trauma system8–12 and the establishment of a trauma center13 14 were particularly efficacious for severe trauma. The number of patients directly transported to NUH increased but the rate of transportation of patients with injuries except for cardiovascular and lung injury did not increase along with implementation of the EMC and TC, probably because the ambulance service triaged the patients appropriately. The decrease in mortality also might result from an increase in the rate of transfer of patients to a higher-level medical institution (table 1). The percentage of transfers to NUH out of those to a higher-level medical institution increased from 6% in 2007 to 31% in 2016 (online supplemental figure). The implementation of the EMC and TC enabled non-NUH hospitals to transfer seriously injured patients promptly to NUH.

Supplementary data

[tsaco-2018-000291supp002.tif]

However, mortality in the patients transported to NUH did not show a significant reduction during the study period although it tended to decrease. If EMC and TC receive more trauma patients including those with mild injuries, the mortality rate usually decreases due to the increase in the denominator. The increase in the number of patients transported to NUH was not so large, which suggested that NUH received only seriously injured patients. It may take a longer time to decrease the mortality rate at NUH although a previous study reported that it takes 3 years for a new TC to catch up to a mature TC.14 In the whole region, however, mortality has declined since 2012 after implementation of the EMC and TC, as shown in figure 3, and the decrease reached significance in 2013 (table 2). These findings suggest that the EMC and TC of NUH had beneficial effects on the region.

One report found that mortality worsened by prolonging the prehospital transportation time.15 In our study, however, although the time was extended, it was not associated with mortality. It might take rather more time to find a hospital to receive patients with mild injury and this may be one of reasons why there was no association with mortality.

Limitations

We acknowledge several limitations in this study. First, our study did not use the Injury Severity Score, a tool for evaluating severity because we could not evaluate it in this ambulance service records. Therefore, we could not analyze mortality adjusted by severity. Second, it is the possibility that advances in clinical practice before and after implementation of the EMC and TC contributed to a decrease in mortality rates. Some studies16 comparing neighboring areas where population and climate are similar showed that a TC still had a beneficial effect on the trauma system. Unfortunately, there were no ambulance service records in other areas in Japan similar to that in Nagasaki prefecture, so such verification could not be performed in the present study. Third, coding was based on personal judgement, so the accuracy of coding was not verified. Also, there was a problem in the definition of each trauma. However, the rate of data collection would decrease by judging codes strictly. It is necessary to investigate methods of accurately performing coding without increasing the burden of the physician. Fourth, we set prognosis at 1 week after injury as the measure of outcome. The main causes of death within 1 week are hemorrhagic shock, tension pneumothorax, cardiac tamponade, and brain death, whereas death due to sepsis or multiple organ failure might not be detected. Although most deaths from trauma, occur within 1 week,17 18 long-term critical care of severely injured patients is important and often more difficult, and longer-term outcomes beyond 1 week are relevant to patients. The outcome also did not include the number of deaths after transfer and after 1 week. We need to follow-up longer time outcomes in the future study. Finally, prehospital comorbidity and functional prognosis was not evaluated. We would like to consider revising the ambulance service record in the future.

Conclusion

We performed analyses using ambulance service records to compare early mortality at a population level before and after the implementation of EMC and TC. Although mortality at NUH did not change significantly, mortality at non-NUH hospitals showed a significant reduction after the EMC and TC at NUH was implemented. As a result, a significant improvement in early mortality was observed at a population level. Our analyses suggested that implementation of a single TC working in cooperation with an EMC contributed to the improvement of early mortality in a regional Japanese city with a population of 500 000.

Acknowledgments

We thank Mr Shinji Sugi and Mr Satoru Hayashida for helping with data analysis. We also thank Nagasaki Medical Control Council for permission for use of ambulance service records.

Footnotes

  • Contributors YT, TM and OT conceived the study concept and study design. SS, NM, TM, MO and OT supervised the conduction of the trial and data collection. SS and OT managed the data, including quality control. SS, GT and MO provided statistical advice on study design and analyzed the data. YT drafted the article, and all authors contributed substantially to its revision. YT and OT take responsibility for the paper as a whole, and all authors are in agreement with the content of the article.

  • Funding This work is supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology in Japan(16H05499, 16K15762).

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval Study approval was obtained from the institutional review board of Nagasaki University Hospital (approval no.: 18111932).

  • Provenance and peer review Not commissioned; externally peer reviewed.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

References

  1. 1.↵
    Annual Report of the Ministry of Health, Labor, and Welfare. 2016. https://www.mhlw.go.jp/toukei/saikin/hw/jinkou/geppo/nengai16/dl/gaikyou28.pdf.
  2. 2.↵
    1. Dinh MM,
    2. Bein KJ,
    3. Gabbe BJ,
    4. Byrne CM,
    5. Petchell J,
    6. Lo S,
    7. Ivers R
    . A trauma quality improvement programme associated with improved patient outcomes: 21 years of experience at an Australian major trauma centre. Injury2014;45:830–4.doi:10.1016/j.injury.2013.11.005
    OpenUrl
  3. 3.↵
    1. Baker CC,
    2. Degutis LC,
    3. DeSantis J,
    4. Baue AE
    . Impact of a trauma service on trauma care in a university hospital. Am J Surg1985;149:453–8.doi:10.1016/S0002-9610(85)80039-8
    OpenUrlCrossRefPubMedWeb of Science
  4. 4.↵
    1. Demetriades D,
    2. Berne TV,
    3. Belzberg H,
    4. Asensio J,
    5. Cornwell E,
    6. Dougherty W,
    7. Alo K,
    8. DeMeester TR
    . The impact of a dedicated trauma program on outcome in severely injured patients. Arch Surg1995;130:216–20.doi:10.1001/archsurg.1995.01430020106020
    OpenUrlCrossRefPubMedWeb of Science
  5. 5.↵
    1. MacKenzie EJ,
    2. Rivara FP,
    3. Jurkovich GJ,
    4. Nathens AB,
    5. Frey KP,
    6. Egleston BL,
    7. Salkever DS,
    8. Scharfstein DO
    . A national evaluation of the effect of trauma-center care on mortality. N Engl J Med2006;354:366–78.doi:10.1056/NEJMsa052049
    OpenUrlCrossRefPubMedWeb of Science
  6. 6.↵
    1. Wang NE,
    2. Saynina O,
    3. Vogel LD,
    4. Newgard CD,
    5. Bhattacharya J,
    6. Phibbs CS
    . The effect of trauma center care on pediatric injury mortality in California, 1999 to 2011. J Trauma Acute Care Surg2013;75:704–16.doi:10.1097/TA.0b013e31829a0a65
    OpenUrlPubMed
  7. 7.↵
    1. Pracht EE
    . Tepas JJ 3rd, Langland-Orban B, Simpson L, Pieper P, FLINT LM. Do pediatric patients with trauma in Florida have reduced mortality rates when treated in designated trauma centers?J Pediatr Surg2008;43:212–21.doi:10.1016/j.jpedsurg.2007.09.047
    OpenUrlCrossRefPubMedWeb of Science
  8. 8.↵
    1. MacKenzie EJ
    . Review of evidence regarding trauma system effectiveness resulting from panel studies. J Trauma1999;47(3 Suppl):S34–41.doi:10.1097/00005373-199909001-00008
    OpenUrlPubMedWeb of Science
  9. 9.↵
    1. Mullins RJ,
    2. Veum-Stone J,
    3. Helfand M,
    4. Zimmer-Gembeck M,
    5. Hedges JR,
    6. Southard PA,
    7. Trunkey DD
    . Outcome of hospitalized injured patients after institution of a trauma system in an urban area. JAMA1994;271:1919–24.doi:10.1001/jama.1994.03510480043032
    OpenUrlCrossRefPubMedWeb of Science
  10. 10.↵
    1. Mullins RJ,
    2. Mann NC
    . Population-based research assessing the effectiveness of trauma systems. J Trauma1999;47(3 Suppl):S59–66.doi:10.1097/00005373-199909001-00013
    OpenUrlPubMedWeb of Science
  11. 11.↵
    1. Mann NC,
    2. Cahn RM,
    3. Mullins RJ,
    4. Brand DM,
    5. Jurkovich GJ
    . Survival among injured geriatric patients during construction of a statewide trauma system. J Trauma2001;50:1111–6.doi:10.1097/00005373-200106000-00022
    OpenUrlCrossRefPubMedWeb of Science
  12. 12.↵
    1. Barquist E,
    2. Pizzutiello M,
    3. Tian L,
    4. Cox C,
    5. Bessey PQ
    . Effect of trauma system maturation on mortality rates in patients with blunt injuries in the finger Lakes region of New York state. J Trauma2000;49:63–70. discussion 9–70.doi:10.1097/00005373-200007000-00009
    OpenUrlPubMed
  13. 13.↵
    1. Sampalis JS,
    2. Lavoie A,
    3. Boukas S,
    4. Tamim H,
    5. Nikolis A,
    6. Fréchette P,
    7. Brown R,
    8. Fleiszer D,
    9. Denis R,
    10. Bergeron E, et al
    . Trauma center designation: initial impact on trauma-related mortality. J Trauma1995;39:232–7. discussion 7–9.
    OpenUrlPubMedWeb of Science
  14. 14.↵
    1. Pracht EE,
    2. Langland-Orban B,
    3. Tepas JJ,
    4. Celso BG,
    5. Flint L
    . Analysis of trends in the Florida trauma system (1991-2003): changes in mortality after establishment of new centers. Surgery2006;140:34–43.doi:10.1016/j.surg.2006.01.012
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Hsia RY,
    2. Srebotnjak T,
    3. Maselli J,
    4. Crandall M,
    5. McCulloch C,
    6. Kellermann AL
    . The association of trauma center closures with increased inpatient mortality for injured patients. J Trauma Acute Care Surg2014;76:1048–54.doi:10.1097/TA.0000000000000166
    OpenUrl
  16. 16.↵
    1. Mullins RJ,
    2. Mann NC,
    3. Hedges JR,
    4. Worrall W,
    5. Jurkovich GJ
    . Preferential benefit of implementation of a statewide trauma system in one of two adjacent states. J Trauma1998;44:609–17. discussion 17.doi:10.1097/00005373-199804000-00009
    OpenUrlPubMedWeb of Science
  17. 17.↵
    1. Shimazaki J,
    2. Tasaki O,
    3. Shiozaki T,
    4. Nakagawa J,
    5. Ikegawa H,
    6. Shimazu T,
    7. Sugimoto H
    . The nationwide survey of patients admitted to emergency medical system centers in Japan. Nihon Kyukyu Igakukai Zasshi2011;22:793–802.doi:10.3893/jjaam.22.793
    OpenUrl
  18. 18.↵
    1. Shakur H,
    2. Roberts I,
    3. Bautista R,
    4. Caballero J,
    5. Coats T,
    6. Dewan Y,
    7. El-Sayed H,
    8. Gogichaishvili T,
    9. Gupta S,
    10. Herrera J, et al
    . Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet2010;376:23–32.doi:10.1016/S0140-6736(10)60835-5
    OpenUrlCrossRefPubMedWeb of Science
PreviousNext
Back to top
Email

Thank you for your interest in spreading the word on TSACO.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Effects of a trauma center on early mortality after trauma in a regional city in Japan: a population-based study
(Your Name) has sent you a message from TSACO
(Your Name) thought you would like to see the TSACO web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Effects of a trauma center on early mortality after trauma in a regional city in Japan: a population-based study
Yuji Takahashi, Shuntaro Sato, Kazunori Yamashita, Naoya Matsumoto, Yoshihiro Nozaki, Tomohito Hirao, Goro Tajima, Takamitsu Inokuma, Shuhei Yamano, Kensuke Takahashi, Takashi Miyamoto, Kenichiro Inoue, Makoto Osaki, Osamu Tasaki
Trauma Surg Acute Care Open Jun 2019, 4 (1) e000291; DOI: 10.1136/tsaco-2018-000291

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Cite This
  • APA
  • Chicago
  • Endnote
  • MLA
Loading
Effects of a trauma center on early mortality after trauma in a regional city in Japan: a population-based study
Yuji Takahashi, Shuntaro Sato, Kazunori Yamashita, Naoya Matsumoto, Yoshihiro Nozaki, Tomohito Hirao, Goro Tajima, Takamitsu Inokuma, Shuhei Yamano, Kensuke Takahashi, Takashi Miyamoto, Kenichiro Inoue, Makoto Osaki, Osamu Tasaki
Trauma Surg Acute Care Open Jun 2019, 4 (1) e000291; DOI: 10.1136/tsaco-2018-000291
Download PDF

Share
Effects of a trauma center on early mortality after trauma in a regional city in Japan: a population-based study
Yuji Takahashi, Shuntaro Sato, Kazunori Yamashita, Naoya Matsumoto, Yoshihiro Nozaki, Tomohito Hirao, Goro Tajima, Takamitsu Inokuma, Shuhei Yamano, Kensuke Takahashi, Takashi Miyamoto, Kenichiro Inoue, Makoto Osaki, Osamu Tasaki
Trauma Surgery & Acute Care Open Jun 2019, 4 (1) e000291; DOI: 10.1136/tsaco-2018-000291
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Respond to this article
  • Tweet Widget
  • Facebook Like
  • Google Plus One
  • Article
    • Abstract
    • Introduction
    • Materials and methods
    • Results
    • Discussion
    • Conclusion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • Info & Metrics
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Atypical profile of aortic injury associated with blunt trauma in the metropolitan area of Japan
  • The TEAM (Trauma Evaluation and Management) course: medical student knowledge gains and retention in the USA versus Ghana
Show more 4th World Trauma Congress Article

Similar Articles

 
 

CONTENT

  • Latest content
  • Archive
  • eLetters
  • Sign up for email alerts
  • RSS

JOURNAL

  • About the journal
  • Editorial board
  • Thank you to our reviewers
  • The American Association for the Surgery of Trauma

AUTHORS

  • Information for authors
  • Submit a paper
  • Track your article
  • Open Access at BMJ

HELP

  • Contact us
  • Reprints
  • Permissions
  • Advertising
  • Feedback form

©Copyright 2022 The American Association for the Surgery of Trauma